Assessment of factors affecting MRI measurement of intracranial volume changes and elastance index
Assessment of factors affecting MRI measurement of intracranial volume changes and elastance index
复制标题
DOI：
10.1080/02688690801911598
复制
发表时间：
2008-06-01
影响因子：
1.1
通讯作者：
Whittle, I.
中科院分区：
文献类型：
--
作者：
Marshall, I.;Maccormick, I.;Whittle, I.
脑流体动力学参数的非侵入性测量在研究和治疗异常颅内压(ICP)方面具有重要意义。通过MRI计算颅内体积的变化和弹性，可以间接评估人体内的颅内压。这两个流体动力学参数是通过对流入和流出大脑的血液、脑脊液流量和心率之间关系的数学分析得出的。这篇论文考察了这三个关键学科特定参数的变异性。三名健康的成年男性三次测量了进出大脑的血液和脑脊液流量。血管系统的个体间差异和心率的个体内差异导致两个受试者的颅内容量电荷和弹性指数的重复性中等(定义为标准差除以平均值)，而第三个受试者的重复性较差。在选择图像平面和要包括的血管时需要特别小心，并且分析对心率的差异非常敏感。由于这些困难，在解释从单一检查中获得的结果时需要谨慎。文中还讨论了降低所得水动力参数变异性的技术和方法。
Non-invasive measurement of cerebral hydrodynamic parameters may be of great use in the study and treatment of conditions involving abnormal intracranial pressure (ICP). ICP can be assessed indirectly in humans by calculation of intracranial volume changes and elastance using MRI. These two hydrodynamic parameters are derived from mathematical analysis of the relationships between blood flow to and from the brain, CSF flow and heart rate. This paper examines the variability in these three critical subject specific parameters. Three healthy adult males had measurements of blood and CSF flow to and from the brain made on three occasions. Inter-individual variation in vasculature and intra-individual variation in heart rates led to modest repeatability (defined as standard deviation divided by the mean) of intracranial volume charge and elastance index in two subjects and poor repeatability in the third. Particular care is required in the selection of image planes and the blood vessels to include, and the analysis is very sensitive to differences in heart-rate. Because of these difficulties, caution is required in the interpretation of results obtained from a single examination. Techniques and methods that may reduce the variability in the derived hydrodynamic parameters are discussed.