Targeting ubiquitin in cancers
Targeting ubiquitin in cancers
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DOI：
10.1016/j.ejca.2006.05.041
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发表时间：
2006-12-01
影响因子：
8.4
通讯作者：
Bernasconi, Paolo
中科院分区：
文献类型：
--
作者：
Dikic, Ivan;Crosetto, Nicola;Bernasconi, Paolo
泛素 (Ub) 是一种小蛋白修饰剂，参与细胞周期、细胞凋亡、细胞信号传导、内吞作用、转录和 DNA 修复等细胞功能。泛素作为一种可逆且高度通用的调节信号发挥作用，可以通过数量不断增加的泛素结合域 (UBD) 来读取和解释。越来越多的证据表明，泛素化或去泛素化酶以及 Ub 结合蛋白的突变或表达改变会影响此类功能的关键介质，并在多种恶性肿瘤中发现。在这里，我们讨论抗癌疗法如何针对 Ub 系统的致癌改变。 (c) 2006 Elsevier Ltd. 保留所有权利。
Ubiquitin (Ub) is a small protein modifier involved in cellular functions such as cell cycle, apoptosis, cell signalling, endocytosis, transcription and DNA repair. Ubiquitin operates as a reversible and highly versatile regulatory signal, which may be read and interpreted by an expanding number of Ub-binding domains (UBD). There is accumulating evidence that mutations or altered expression of ubiquitylating or de-ubiquitylating enzymes as well as of Ub-binding proteins affect crucial mediators of such functions and are found in several malignancies. Here we discuss how oncogenic alterations in the Ub system can be targeted by anti-cancer therapies. (c) 2006 Elsevier Ltd. All rights reserved.