Design Strategies for Responsive Fluorine‐19 Magnetic Resonance Probes Using Paramagnetic Metal Complexes
Design Strategies for Responsive Fluorine‐19 Magnetic Resonance Probes Using Paramagnetic Metal Complexes
复制标题
使用顺磁性金属配合物的响应性氟 19 磁共振探针的设计策略
DOI：
10.1002/anse.202200041
复制
发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Que, Emily L.
中科院分区：
文献类型：
--
作者：
Ryan, Raphael T.;Scott, Kathleen M.;Que, Emily L.
磁共振成像（MRI）是一种功能强大且广泛使用的体内成像技术，可在无电离辐射的情况下进行全身成像。在临床实践中，1H MRI用于通过监测水和脂质中的质子来成像解剖和生理状态。为了在分子水平上监测生物化学过程，一些研究小组正在探索响应性MRI试剂，这些试剂在与感兴趣的分析物或生物环境相互作用时改变其信号。由于19 F核具有与质子相似的磁共振（MR）特性，并且在生命系统中不存在内源性19 F，因此没有背景信号，因此氟（19 F）MRI剂是有前途的。为了使19 F磁共振分子成像和分析的响应剂，氟化平台必须开发，其中它们的19 F磁共振信号的变化后，与目标分析物的相互作用。一个有希望的策略是使用顺磁性金属通过改变弛豫速率和/或附加的19 F成像标记的化学位移来调制19 F MR信号。在这个概念中，我们提供了一个概述的理论原理和分子设计策略，已被利用在responsive 19 F MR代理的设计，特别关注基于小分子顺磁性金属离子螯合物的代理。
Magnetic resonance imaging (MRI) is a powerful and widely used in vivo imaging technique that enables whole body imaging without ionizing radiation. In clinical practice,1H MRI is employed for imaging anatomical and physiological states via monitoring of protons in water and lipids. In order to monitor biochemical processes at the molecular level, several research groups are exploring responsive MRI agents that alter their signal upon interaction with an analyte or biological environment of interest. Fluorine (19F) MRI agents are promising due to the19F nucleus having similar magnetic resonance (MR) properties to proton and the absence of endogenous19F in living systems, resulting in no background signal. In order to make responsive19F MR agents for molecular imaging and analysis, fluorinated platforms must be developed in which their19F MR signal changes after interacting with a target analyte. A promising strategy is to use paramagnetic metals to modulate the19F MR signal by altering the relaxation rates and/or chemical shift of an appended19F imaging tag. In this concept, we provide an overview of the theoretical principles and molecular design strategies that have been exploited in the design of responsive19F MR agents, with a specific focus on agents based on small molecule paramagnetic metal ion chelates.