Electrochemical Aminoselenation and Oxyselenation of Styrenes with Hydrogen Evolution
Electrochemical Aminoselenation and Oxyselenation of Styrenes with Hydrogen Evolution
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苯乙烯的电化学氨硒化和氧硒化析氢
DOI：
10.1021/acs.orglett.8b03274
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发表时间：
2019
期刊：
影响因子：
5.2
通讯作者：
Lei Aiwen
中科院分区：
文献类型：
--
作者：
Sun Li;Yuan Yong;Yao Min;Wang Han;Wang Daoxin;Gao Meng;Chen Yi-Hung;Lei Aiwen
使用无添加剂的条件是从现成的不饱和底物制备有机硒试剂的理想方法。因此，我们报道了在没有任何酸或氧化剂作为添加剂的情况下，电诱导苯乙烯的氨基硒和氧化硒的反应。这种转变与各种官能团相容，从而导致邻位的双官能化有机硒化合物。我们的策略提高了该协议在制药行业使用的潜力。在初步机理研究的基础上，我们提出了两条可能的途径。
The use of additive-free conditions is an ideal approach to prepare organoselenium reagents from readily available unsaturated substrates. Thus, we report the electro-induced aminoselenation and oxyselenation of styrenes without any acids or oxidants as additives. This transformation is compatible with various functional groups, which leads to vicinal difunctionalized organoselenium compounds. Our strategy improves the potential of this protocol for use in the pharmaceutical industry. Based upon the preliminary mechanism studies, we propose two possible pathways.