PROGRESSION OF GLOMERULAR SCLEROSIS IN EXPERIMENTAL UREMIC RATS BY ADMINISTRATION OF INDOLE, A PRECURSOR OF INDOXYL SULFATE
PROGRESSION OF GLOMERULAR SCLEROSIS IN EXPERIMENTAL UREMIC RATS BY ADMINISTRATION OF INDOLE, A PRECURSOR OF INDOXYL SULFATE
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给予硫酸吲哚酚前体吲哚对实验性尿毒症大鼠肾小球硬化进展的影响
DOI：
10.1159/000168716
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发表时间：
1994-05-01
影响因子：
4.2
通讯作者：
MIYAZAKI, T
中科院分区：
文献类型：
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作者：
NIWA, T;ISE, M;MIYAZAKI, T
在尿毒症中，由于硫酸吲哚酚的肾清除率降低，硫酸吲哚酚的血清水平显著升高。硫酸吲哚酚是由肠道细菌产生的吲哚在肝脏中合成的。为了确定硫酸吲哚酚在慢性肾功能衰竭进展中的作用，我们给次全肾切除尿毒症大鼠注射吲哚，硫酸吲哚酚的前体。吲哚的口服给药增加了血清肌酐和血尿素氮水平，降低了肌酐、菊粉和对氨基马尿酸的清除率。吲哚组大鼠肾小球硬化指数明显高于对照组。口服给药后，尿液中未检测到吲哚，但有大量的代谢产物硫酸吲哚酚。因此，吲哚管理刺激肾小球硬化尿毒症模型通过生产硫酸吲哚酚。
In uremia there is a marked elevation of serum levels of indoxyl sulfate due to its decreased renal clearance. Indoxyl sulfate is synthesized in the liver from indole which is produced by bacteria in the intestines. To determine the role of indoxyl sulfate in the progression of chronic renal failure, we administered indole, the precursor of indoxyl sulfate, to subtotally nephrectomized uremic rats. The oral administration of indole increased the serum levels of creatinine and blood urea nitrogen and decreased creatinine, inulin, and p-aminohippuric acid clearances. The glomerular sclerosis index in the indole-treated rats was higher than in the control uremic rats. After oral administration, indole could not be detected in the urine, but large amounts of its metabolite, indoxyl sulfate. Thus, indole administration stimulated glomerular sclerosis in a uremic model through the production of indoxyl sulfate.