Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
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DOI：
10.1056/nejmoa035275
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发表时间：
2003-11-13
影响因子：
158.5
通讯作者：
Pollak, P
中科院分区：
文献类型：
--
作者：
Krack, P;Batir, A;Pollak, P
背景资料：虽然在晚期帕金森病患者的丘脑底核的双边刺激的短期效益已被很好地记录，该程序的长期结果是unknown.Methods：我们进行了为期五年的前瞻性研究的第一个连续49例患者，我们治疗的丘脑底核的双边刺激。患者在1年、3年和5年接受左旋多巴（药物治疗）和不接受左旋多巴（停止药物治疗）的评估，使用统一帕金森病评定量表。结果：与基线相比，停药后5年的运动功能评分提高了54%（P
Background: Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown.Methods: We conducted a five-year prospective study of the first 49 consecutive patients whom we treated with bilateral stimulation of the subthalamic nucleus. Patients were assessed at one, three, and five years with levodopa (on medication) and without levodopa (off medication), with use of the Unified Parkinson's Disease Rating Scale. Seven patients did not complete the study: three died, and four were lost to follow-up.Results: As compared with base line, the patients' scores at five years for motor function while off medication improved by 54 percent (P