Engineering cell factories for producing building block chemicals for bio-polymer synthesis.
Engineering cell factories for producing building block chemicals for bio-polymer synthesis.
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DOI：
10.1186/s12934-016-0411-0
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发表时间：
2016-01-21
影响因子：
6.4
通讯作者：
Kondo A
中科院分区：
文献类型：
--
作者：
Tsuge Y;Kawaguchi H;Sasaki K;Kondo A
合成聚合物广泛应用于日常生活中。由于与全球变暖和石油储量耗尽相关的环境问题日益增加，期望开发用于从可再生资源生产聚合物结构单元化学品的基于微生物的发酵方法以取代目前的基于石油的方法。为此，需要以高产率和生产力有效生产目标化学品的菌株。代谢工程的最新进展已经通过控制朝向目标化学品的碳通量而使得能够以高产率和生产率生物合成聚合物化合物。使用这些方法，微生物菌株已经被改造以生产用于替代传统石油衍生的脂肪族聚合物的单体化学品。这些发展也提高了微生物生产芳香族化学品的可能性，用于合成具有所需性质的高性能聚合物，如紫外线吸收，高耐热性和机械强度。在本综述中，我们总结了代谢工程方法的最新进展，以优化微生物菌株生产的积木合成脂肪族和高性能芳香族聚合物。本文的在线版本（doi：10.1186/s12934-016-0411-0）包含补充材料，可供授权用户使用。
Synthetic polymers are widely used in daily life. Due to increasing environmental concerns related to global warming and the depletion of oil reserves, the development of microbial-based fermentation processes for the production of polymer building block chemicals from renewable resources is desirable to replace current petroleum-based methods. To this end, strains that efficiently produce the target chemicals at high yields and productivity are needed. Recent advances in metabolic engineering have enabled the biosynthesis of polymer compounds at high yield and productivities by governing the carbon flux towards the target chemicals. Using these methods, microbial strains have been engineered to produce monomer chemicals for replacing traditional petroleum-derived aliphatic polymers. These developments also raise the possibility of microbial production of aromatic chemicals for synthesizing high-performance polymers with desirable properties, such as ultraviolet absorbance, high thermal resistance, and mechanical strength. In the present review, we summarize recent progress in metabolic engineering approaches to optimize microbial strains for producing building blocks to synthesize aliphatic and high-performance aromatic polymers. The online version of this article (doi:10.1186/s12934-016-0411-0) contains supplementary material, which is available to authorized users.