Oxidative Coupling of 3-Oxindoles with Indoles and Arenes.
Oxidative Coupling of 3-Oxindoles with Indoles and Arenes.
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DOI：
10.1002/cssc.201900438
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发表时间：
2019-05
期刊：
影响因子：
8.4
通讯作者：
Houng Kang;Adriana L. Jemison;E. Nigro;M. Kozlowski
中科院分区：
文献类型：
--
作者：
Houng Kang;Adriana L. Jemison;E. Nigro;M. Kozlowski
本文介绍了一种由2-取代的3-羟吲哚与芳香族化合物氧化偶联生成2，2-二取代吲哚啉-3-酮的高效方法。这项工作利用氧气作为终端氧化剂和贱金属催化剂在温和的条件下，而不是有毒/贵金属试剂和高分子量的氧化剂。在没有预官能化的情况下，以中等至优异的产率（高达96%）产生四元结构。
A highly efficient method for the oxidative coupling of 2-substituted 3-oxindoles with aromatic compounds to form 2,2-disubstituted indolin-3-ones with broad scope is described. This work utilized oxygen as the terminal oxidant and a base-metal catalyst under mild conditions instead of toxic/precious-metal reagents and higher-molecular-weight oxidants. Quaternary structures were produced in modest-to-excellent yields (up to 96 %) without prefunctionalization.