The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
The cytoplasmic expression of MUC1 in papillary thyroid carcinoma of different histological variants and its correlation with cyclin D1 overexpression
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DOI：
10.1007/s12022-007-0012-x
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发表时间：
2007-06-01
影响因子：
4.4
通讯作者：
Yamashita, Shunichi
中科院分区：
文献类型：
--
作者：
Abrosimov, Alexander;Saenko, Vladimir;Yamashita, Shunichi
本研究探讨了MUC 1在不同组织类型、大小和侵袭性形态特征的甲状腺乳头状癌（PTC）中的免疫组化表达及其与Writ通路靶分子cyclin D1过表达的相关性。在总共209个PTC中检测MUC1表达。在高柱状细胞和嗜酸细胞变体（100%）、Warthin样（78%）和常规PTC（61%）以及具有常规生长模式的乳头状微小癌（PMC）（52%）中，胞质MUCI表达升高。相反，在PTC的滤泡变体（27%）和具有滤泡结构的PMCs（13%）中，它是低的。胞浆MUC1积聚与任何临床病理特征无关，除了PTC和PMC中具有常规生长模式的瘤周淋巴样浸润。MUC1染色与细胞周期蛋白D1在传统PTC和PMC以及具有滤泡结构的PMC中的过表达相关。结果表明，MUC1的表达在PTC的不同组织学变体中变化很大，在具有滤泡结构的肿瘤中最低。一般来说，它并不能证明是PTC攻击性的指示器。MUC1和细胞周期蛋白D1之间的高度相关性意味着MUC1参与了人PTC和PMC的大子集中的Writ级联功能。
This study addressed the immumohistochemical expression of MUC1 in papillary thyroid carcinoma (PTC) of different histotypes, sizes, and morphological features of aggressiveness, and its correlation with the overexpression of cyclin D 1, a target molecule of the Writ pathway. MUC1 expression was examined in a total of 209 PTCs. Cytoplasmic MUCI expression was elevated in the tall, columnar cell and oncocytic variants (100%), Warthin-like (78%), and conventional PTCs (61%), and in papillary microcarcinoma (PMC) with the conventional growth pattern (52%). On the contrary, it was low in the follicular variant (27%) of PTC and PMCs with follicular architecture (13%). Cytoplasmic MUC1 accumulation did not associate with any clinicopathological features except peritumoral lymphoid infiltration in PTCs and in PMCs with the conventional growth pattern. MUC1 staining correlated with cyclin D1 overexpression in conventional PTCs and PMCs and PMCs with follicular architecture. The results demonstrate that MUC1 expression varies broadly in different histological variants of PTC, being the lowest in tumors with follicular structure. In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Writ cascade functioning in a large subset of human PTCs and PMCs.