Residue depletion of nitrofuran drugs and their tissue-bound metabolites in channel catfish (Ictalurus punctatus) after oral dosing
Residue depletion of nitrofuran drugs and their tissue-bound metabolites in channel catfish (Ictalurus punctatus) after oral dosing
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DOI：
10.1021/jf801398p
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发表时间：
2008-09-10
影响因子：
6.1
通讯作者：
Plakas, Steven M.
中科院分区：
文献类型：
--
作者：
Chu, Pak-Sin;Lopez, Mayda I.;Plakas, Steven M.
经口给药（1 mg/kg体重）后，检查了硝基呋喃类药物呋喃唑酮、呋喃西林、呋喃他酮和呋喃妥因及其组织结合代谢物[分别为3-氨基-2-恶唑烷酮（AOZ）、氨基脲（SC）、3-氨基-5-吗啉甲基-2-恶唑烷酮（AMOZ）和1-氨基乙内酰脲（AH）]在癍点叉尾鮰肌肉中的消耗情况。母体药物在2 h内可在肌肉中测量。呋喃唑酮（30.4 ng/g）在4 h时达到峰值，而呋喃西林、呋喃他酮和呋喃妥因（分别为104、35.2和9.8 ng/g）在12 h时达到峰值。母体药物从肌肉中迅速消除，96 h时组织浓度降至检测限（1 ng/g）以下。在12 h时测量组织结合AMOZ和AOZ的峰值水平（分别为46.8和33.7 ng/g），在24 In时测量SC和AH的峰值水平（分别为31.1和9.1 ng/g）。组织结合代谢物可在给药后长达56天内测量。这些结果支持使用组织结合的代谢物作为目标分析物用于监测硝基呋喃类药物在癍点叉尾鮰。
The depletion of the nitrofuran drugs furazolidone, nitrofurazone, furaltadone, and nitrofurantoin and their tissue-bound metabolites [3-amino-2-oxazolidinone (AOZ), semicarbazide (SC), 3-amino-5-morpholinomethyl-2-oxazolidinone (AMOZ), and 1-aminohydantoin (AH), respectively] were examined in the muscle of channel catfish following oral dosing (1 mg/kg body weight). Parent drugs were measurable in muscle within 2 h. Peak levels were found at 4 h for furazolidone (30.4 ng/g) and at 12 h for nitrofurazone, furaltadone, and nitrofurantoin (104, 35.2, and 9.8 ng/g respectively). Parent drugs were rapidly eliminated from muscle, and tissue concentrations fell below the limit of detection (1 ng/g) at 96 h. Peak levels of tissue-bound AMOZ and AOZ (46.8 and 33.7 ng/g respectively) were measured at 12 h, and of SC and AH (31.1 and 9.1 ng/g, respectively) at 24 In. Tissue-bound metabolites were measurable for up to 56 days postdose. These results support the use of tissue-bound metabolites as target analytes for monitoring nitrofuran drugs in channel catfish.