Adhesion molecules in the stem cell niche - more than just staying in shape?
Adhesion molecules in the stem cell niche - more than just staying in shape?
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DOI：
10.1242/jcs.054312
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发表时间：
2010-05-15
影响因子：
4
通讯作者：
ffrench-Constant, Charles
中科院分区：
文献类型：
--
作者：
Marthiens, Veronique;Kazanis, Ilias;ffrench-Constant, Charles
干细胞在其微环境中表达粘附分子已得到很好的描述，但它们的功能是什么？传统观点认为，这些粘附分子只是将干细胞保留在微环境中，从而维持其结构和形状。在这里，我们回顾了最近的文献，表明这只是它们的作用之一，并且它们在干细胞-生态位相互作用的各个方面（保留、分裂和退出）具有重要功能。我们还从该文献中强调了支持一个简单模型的证据，即中心体定位和纺锤体角度的调节由钙粘蛋白和整合素调节，并且这两种粘附分子的差异活性使得干细胞的基本特性能够在不对称和对称分裂之间切换。
The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and shape. Here, we review recent literature showing that this is but one of their roles, and that they have essential functions in all aspects of the stem cell-niche interaction - retention, division and exit. We also highlight from this literature evidence supporting a simple model whereby the regulation of centrosome positioning and spindle angle is regulated by both cadherins and integrins, and the differential activity of these two adhesion molecules enables the fundamental stem cell property of switching between asymmetrical and symmetrical divisions.