Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications.
Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications.
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肿瘤缺氧的最新进展：肿瘤进展、分子机制和治疗意义。
DOI：
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发表时间：
2007
影响因子：
3.1
通讯作者：
Changyi J. Chen
中科院分区：
文献类型：
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作者：
Yuqing Zhang;Min Li;Q. Yao;Changyi J. Chen
肿瘤的氧合状态受到严格的调控，并与其侵袭行为相关。缺氧在肿瘤血管生成、突变率、转移以及对放化疗的抵抗等方面起着至关重要的作用。许多分子通路已被认为在肿瘤中介导这些低氧诱导的反应。例如，大量研究表明，低氧诱导因子-1(HIF-1)是调节肿瘤对低氧反应的关键分子。许多其他基因，包括生长因子、糖酵解酶、细胞因子和转录因子，都可以通过HIF-1依赖或HIF-1非依赖的途径在缺氧中诱导。本文从肿瘤低氧检测新技术、临床和动物研究、细胞培养模型、低氧诱导的关键分子和治疗意义等方面综述了肿瘤低氧的研究进展。这些有价值的信息对于临床医生和研究人员来说尤其及时和有帮助，他们想要了解该领域的最新努力，并确定可能的肿瘤缺氧研究路线。
Tumor oxygenation status is tightly regulated and correlates with its aggressive behavior. Hypoxia plays critical roles in tumor progression including tumor angiogenesis, mutation rate, metastasis and resistance to radiation and chemotherapy. Many molecular pathways have been recognized to mediate these hypoxia-induced responses in tumors. For example, extensive studies demonstrate that hypoxia-inducible factor-1 (HIF-1) is a key molecule in regulating tumor responses to hypoxia. Many other genes including growth factors, glycolytic enzymes, cytokines, and transcription factors are inducible by hypoxia via either HIF-1-dependent or HIF-1-independent pathways. This review summarizes current advances in tumor hypoxia regarding new technologies of tumor hypoxia measurement, clinical and animal studies, cell culture models, the hypoxia-induced key molecules and therapeutic implications. This valuable information is particularly timely and helpful for clinicians and researchers who want to recognize the newest endeavors within the field and identify possible lines of investigation in tumor hypoxia.