Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases.
Antigen Processing, Presentation, and Tolerance: Role in Autoimmune Skin Diseases.
复制标题
DOI：
10.1016/j.jid.2021.05.009
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
J. Prinz
中科院分区：
文献类型：
--
作者：
J. Prinz
自身反应性 T 细胞对携带某些 HLA 风险等位基因的遗传易感个体存在出现自身免疫性皮肤病的持续风险。免疫耐受机制与广泛的 HLA 呈递的自身免疫肽组、多特异性 TCR 的预定义库、B 细胞中 Ig 基因的体细胞重组不断产生新的抗体特异性以及增强的促炎反应性相抵触。 HLA分子自身抗原呈递的增加、病原体诱导的T细胞针对自体结构的交叉激活、自身蛋白代谢的改变以及促炎信号的过度产生都可能导致免疫耐受的破坏和自身免疫性皮肤病的发展。
Autoreactive T cells pose a constant risk for the emergence of autoimmune skin diseases in genetically predisposed individuals carrying certain HLA risk alleles. Immune tolerance mechanisms are opposed by broad HLA-presented self-immunopeptidomes, a predefined repertoire of polyspecific TCRs, the continuous generation of new antibody specificities by somatic recombination of Ig genes in B cells, and heightened proinflammatory reactivity. Increased autoantigen presentation by HLA molecules, cross-activation of pathogen-induced T cells against autologous structures, altered metabolism of self-proteins, and excessive production of proinflammatory signals may all contribute to the breakdown of immune tolerance and the development of autoimmune skin diseases.