Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.
Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.
复制标题
DOI：
10.1021/ol006810x
复制
发表时间：
2001-01
期刊：
影响因子：
5.2
通讯作者：
G. Zhao;U. C. Deo;B. Ganem
中科院分区：
文献类型：
--
作者：
G. Zhao;U. C. Deo;B. Ganem
[图：见文]1- n -亚氨基糖（1-偶氮糖）是一类具有良好生物医学应用前景的新型糖苷酶抑制剂，目前已开发出一种高效高产的不对称合成策略。采用高度区域选择性的1,2-取代吡啶还原过程，将烟酸甲酯转化为几种具有代表性的1-偶氮糖。
[figure: see text] An efficient, high-yielding strategy has been developed for the asymmetric synthesis of 1-N-iminosugars (1-azasugars), a new class of glycosidase inhibitors with promising biomedical applications. A highly regioselective procedure for the 1,2-reduction of substituted pyridines was employed to transform methyl nicotinate into several representative 1-azasugars.