Differences in Cognitive Impairment in Primary Age-Related Tauopathy Versus Alzheimer Disease
Differences in Cognitive Impairment in Primary Age-Related Tauopathy Versus Alzheimer Disease
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DOI：
10.1093/jnen/nly132
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发表时间：
2019-03-01
影响因子：
3.2
通讯作者：
Crary, John F.
中科院分区：
文献类型：
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作者：
Besser, Lilah M.;Mock, Charles;Crary, John F.
本研究利用国家阿尔茨海默病协调中心的横断面数据，研究了原发性年龄相关 tau 蛋白病 (PART) 和阿尔茨海默病 (AD) 患者之间神经心理学测试分数的差异。线性回归测试了按认知状态分层的 4 个认知领域的差异（全球临床痴呆评级 [CDR]）。样本包括 240 名没有神经炎斑块 (NP) 的参与者（明确的 PART）、186 名患有稀疏 NP（可能是 PART）的参与者以及 510 名患有中度/频繁 NP (AD) 的参与者。使用 12 项神经心理学测试计算四个认知领域 z 分数结果变量（记忆、注意力、执行功能和语义记忆/语言）。与 AD 患者相比，确定 PART 参与者的语义记忆/语言较少，对于 CDR = 0.5 或 1 的患者，平均调整 z 得分差异为 0.37（95% 置信区间 [CI]：0.16-0.58）；对于 CDR = 2 或 3 的患者，平均调整 z 得分差异为 0.92（CI：0.22-1.63）。与 AD 参与者相比，CDR = 的确定 PART 参与者0.5 或 1 人具有记忆保留（调整后的 z 分数差异：0.61；CI：0.39-0.84），并且 CDR = 2 或 3 的明确 PART 参与者具有注意力保留（调整后的 z 分数差异：0.76：CI：0.09-1.43）。明确的 PART 和 AD 之间的认知障碍模式不同，表明这两组个体之间的临床表现存在显着差异。
This study examined differences in neuropsychological test scores between individuals with primary age-related tauopathy (PART) and Alzheimer disease (AD) using cross-sectional data from the National Alzheimer's Coordinating Center. Linear regression tested for differences in 4 cognitive domains stratified by cognitive status (global Clinical Dementia Rating [CDR]). The sample included 240 participants with no neuritic plaques (NP) (definite PART), 186 with sparse NP (possible PART), and 510 with moderate/frequent NP (AD). Four cognitive domain z-score outcome variables (memory, attention, executive function, and semantic memory/language) were calculated using 12 neuropsychological tests. Definite PART participants had a sparing of semantic memory/language compared to those with AD, with a mean adjusted z-score difference of 0.37 (95% confidence interval [CI]: 0.16-0.58) for those with CDR = 0.5 or 1 and of 0.92 (CI: 0.22-1.63) for those with CDR = 2 or 3. Compared to participants with AD, definite PART participants with CDR = 0.5 or 1 had sparing of memory (adjusted z-score difference: 0.61; CI: 0.39-0.84) and definite PART participants with CDR = 2 or 3 had sparing of attention (adjusted z-score difference: 0.76: CI: 0.09-1.43). Patterns of cognitive impairment differed between definite PART and AD, suggesting significant differences in clinical presentation between individuals from these 2 groups.