Experimental infection of chimpanzees with the HBsAg‐Associated delta (δdL) agent: An ultrastructural study
Experimental infection of chimpanzees with the HBsAg‐Associated delta (δdL) agent: An ultrastructural study
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HBsAg 相关 δ (δdL) 制剂对黑猩猩的实验性感染：一项超微结构研究
DOI：
10.1002/jmv.1890130108
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发表时间：
1984
影响因子：
12.7
通讯作者：
R. Purcell
中科院分区：
文献类型：
--
作者：
M. G. Canese;M. Rizzetto;R. Novara;W. London;R. Purcell
通过电子显微镜在接种人血清的黑猩猩肝活检组织中观察到特征性细胞质膜结构和核内颗粒聚集体，与非甲非B型肝炎中报告的相似，人血清对δ因子具有感染性。在肝内产生δdL抗原期间，超微结构变化最大，但也独立于δdL‐Ag表达检测到。超微结构的相似性进一步证明了δdL具有不同于HBV的性质。
Characteristic cytoplasmic membranous structures and intranuclear aggregates of particles similar to those reported in non‐A, non‐B hepatitis were observed by electron microscopy in the liver biopsies of chimpanzees inoculated with human serum, infectious for the delta agent. The ultrastructural changes were maximal during the intrahepatic production of the δdL antigen, but were detected also independently of δdL‐Ag expression. The ultrastructural analogies provide further evidence that δdL has properties distinct from HBV.
非甲非乙型肝炎患者肝细胞的核变化。
影响因子：
29.4
作者：
Cabral,GA;Marciano-Cabral,F;Patterson,M;Galen,EA;Carithers,RL
通讯作者：
Carithers,RL