Olfactory Training in Patients with Parkinson's Disease
Olfactory Training in Patients with Parkinson's Disease
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DOI：
10.1371/journal.pone.0061680
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发表时间：
2013-04-17
期刊：
影响因子：
3.7
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
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作者：
Haehner, Antje;Tosch, Clara;Hummel, Thomas
目的：帕金森病(PD)患者嗅觉功能下降是一个被广泛研究的事实。研究表明，药物治疗帕金森病不能恢复患者的嗅觉功能。这项调查的目的是，帕金森病患者是否会从气味训练中受益，从而改善他们的一般嗅觉功能。本研究假设嗅觉训练能提高受试者对训练过程中气味的敏感度，并提高嗅觉功能。方法：我们招募了70名帕金森病患者和嗅觉丧失患者参加这项单中心、前瞻性、对照的非盲法研究。35名患者被分配到嗅觉训练组，35名受试者被分配到对照组(不进行训练)。在为期12周的嗅觉训练期间，患者每天两次暴露在四种气味(苯乙醇：玫瑰、桉树：桉树、香茅醛：柠檬和丁香酚：丁香)中。除训练过程中使用的气味阈值测试外，在训练前后使用嗅觉棒(苯乙醇阈值、气味辨别测试和气味识别测试)进行嗅觉测试。结果：与基线相比，训练组PD患者的嗅觉功能显著提高，这是观察到的鼻烟棒测试分数和训练过程中使用的气味阈值。未进行嗅觉训练的PD患者嗅觉功能无明显变化。结论：嗅觉训练可提高PD患者的嗅觉敏感度。
Objective: Decrease of olfactory function in Parkinson's disease (PD) is a well-investigated fact. Studies indicate that pharmacological treatment of PD fails to restore olfactory function in PD patients. The aim of this investigation was whether patients with PD would benefit from "training" with odors in terms of an improvement of their general olfactory function. It has been hypothesized that olfactory training should produce both an improved sensitivity towards the odors used in the training process and an overall increase of olfactory function.Methods: We recruited 70 subjects with PD and olfactory loss into this single-center, prospective, controlled non-blinded study. Thirty-five patients were assigned to the olfactory training group and 35 subjects to the control group (no training). Olfactory training was performed over a period of 12 weeks while patients exposed themselves twice daily to four odors (phenyl ethyl alcohol: rose, eucalyptol: eucalyptus, citronellal: lemon, and eugenol: cloves). Olfactory testing was performed before and after training using the "Sniffin' Sticks" (thresholds for phenyl ethyl alcohol, tests for odor discrimination, and odor identification) in addition to threshold tests for the odors used in the training process.Results: Compared to baseline, trained PD patients experienced a significant increase in their olfactory function, which was observed for the Sniffin' Sticks test score and for thresholds for the odors used in the training process. Olfactory function was unchanged in PD patients who did not perform olfactory training.Conclusion: The present results indicate that olfactory training may increase olfactory sensitivity in PD patients.