Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.
Increased CD11b+ Gr-1+ cell population in the placenta after infection with Toxoplasma gondii.
复制标题
弓形虫感染后胎盘中 CD11b Gr-1 细胞群增加。
DOI：
10.1111/1348-0421.12225
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Shibuya K.
中科院分区：
文献类型：
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作者：
Takeshima K;Sato K;Nabekura T;Nagamune K;Hamada H;Yoshikawa H;Shibuya A;Shibuya K.
刚地弓形虫是一种专性细胞内原生动物病原体，可以穿过胎盘，导致先天性弓形虫病，严重的胎儿大脑异常。抗t免疫反应的分子机制。胎盘中的弓形虫感染在很大程度上仍不清楚。建立了一种用流式细胞术表征胎盘免疫细胞表型的分析方法，发现t后胎盘中CD11b+Gr‐1+细胞数量显著增加。gondiiinfection。这些结果表明，先天免疫反应在抗t免疫中起重要作用。经母体-胎儿界面的gondii感染。
Toxoplasma gondii is an obligate intracellular protozoan pathogen that can cross the placenta, resulting in congenital toxoplasmosis with severe fetal brain abnormalities. The molecular mechanisms of immune responses againstT. gondiiinfection in the placenta have largely remained unclear. An analytical method for characterizing phenotypes of immune cells in the placenta by flow cytometry was established and it was found that numbers of CD11b+Gr‐1+cells in the placenta increased significantly afterT. gondiiinfection. These results suggest that innate immune responses play an important role in immunity againstT. gondiiinfection via the feto‐maternal interface.