Inefficient Vaginal Transmission of Tenofovir-Resistant HIV-1
Inefficient Vaginal Transmission of Tenofovir-Resistant HIV-1
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DOI：
10.1128/jvi.01777-12
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发表时间：
2013-01-01
影响因子：
5.4
通讯作者：
Garcia, J. Victor
中科院分区：
文献类型：
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作者：
Chateau, Morgan;Swanson, Michael D.;Garcia, J. Victor
耐药艾滋病毒的传播被认为是对目前一线抗逆转录病毒治疗（ART）方案和正在测试的几种基于抗逆转录病毒的暴露前预防（PrEP）策略的有效性的威胁。在这里，我们评估了常见的替诺福韦（TFV）耐药突变K65 R对阴道HIV传播的影响。我们的研究结果表明，尽管没有明显的整体复制能力在体内的损失，这种突变的结果显着减少粘膜传输。当传播时，突变病毒最终在3只动物中的2只中恢复为野生型。
Transmission of drug-resistant HIV has been postulated to be a threat to current first-line antiretroviral therapy (ART) regimens and the efficacy of several antiretroviral-based preexposure prophylaxis (PrEP) strategies being tested. Here we evaluated the effect of the common tenofovir (TFV) resistance mutation K65R on vaginal HIV transmission. Our results demonstrate that despite no overt loss of overall replication competence in vivo, this mutation results in significantly reduced mucosal transmission. When transmitted, the mutant virus eventually reverted to the wild type in 2 of 3 animals examined.