Intranasal oxytocin reduces pre-courtship aggression and increases paternal response in California mice (Peromyscus californicus)
Intranasal oxytocin reduces pre-courtship aggression and increases paternal response in California mice (Peromyscus californicus)
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DOI：
10.1016/j.physbeh.2022.113773
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发表时间：
2022-03-16
影响因子：
2.9
通讯作者：
Marler，Catherine A.
中科院分区：
文献类型：
--
作者：
Guoynes，Caleigh D.;Marler，Catherine A.
催产素（OXT）是一种神经肽，可以促进亲社会行为，减少社会压力和焦虑，但在某些情况下也可以增加攻击性。我们研究了鼻内（IN）OXT的急性脉冲是否会影响野生小鼠在整个生命周期中可能发生的社会挑战期间的社会行为。为了测试这一点，我们研究了急性效应的IN OXT在雄性加州小鼠（Peromyscus californicus），一夫一妻制，双亲，和领土啮齿动物，使用受试者内纵向设计。社会挑战包括求爱前的男女相遇，在（1）最初的侵略性，而不是随后的亲和阶段的求爱，（2）同性居民入侵者测试，（3）父母照顾测试。连续性试验和剂量间隔至少两周。雄性动物在每次行为测试前5分钟接受0.8 IU/kg OXT或生理盐水对照鼻内输注，共接受IN OXT或生理盐水对照治疗3次。我们预测，IN OXT将1）在求爱前的攻击阶段减少攻击和增加联系，2）在居民入侵者范例中增加攻击，3）在父亲照顾测试中增加父亲照顾和发声。正如所预测的那样，在求爱前的侵略与一个新的女性，在OXT男性表现出较少的接触侵略比控制男性，虽然没有变化的亲和行为。然而，配对后，在居民入侵者测试，在OXT男性没有不同的控制男性接触侵略。在父亲的照顾测试中，IN OXT雄性比对照雄性更快地接近他们的幼崽，但在发声方面没有差异，不像我们以前的研究表明对雌性发声的影响。总之，在求爱前的攻击和父亲的照顾测试中，IN OXT减少了反社会行为;然而，在居民入侵者测试中，IN OXT并没有改变反社会行为。这些数据表明，IN OXT促进亲社会行为，特别是在社会背景下，可以导致从属关系。
Oxytocin (OXT) is a neuropeptide that can facilitate prosocial behavior and decrease social stress and anxiety but can also increase aggression in some contexts. We investigated whether acute pulses of intranasal (IN) OXT influenced social behavior during social challenges that are likely to occur throughout the lifespan of a wild mouse. To test this, we examined the acute effects of IN OXT in the male California mouse (Peromyscus californicus), a monogamous, biparental, and territorial rodent, using a within-subjects longitudinal design. Social challenges included a pre-courtship male-female encounter conducted during the (1) initial aggressive and not the following affiliative phase of courtship, (2) same-sex resident intruder test, and (3) parental care test. Consecutive tests and doses were separated by at least two weeks. Males were treated with intranasal infusions of 0.8 IU/kg OXT or saline controls 5-min before each behavioral test, receiving a total of three treatments of either IN OXT or saline control. We predicted that IN OXT would 1) decrease aggression and increase affiliation during the pre-courtship aggression phase, 2) increase aggression during resident intruder paradigms, and 3) increase paternal care and vocalizations during a paternal care test. As predicted, during pre-courtship aggression with a novel female, IN OXT males displayed less contact aggression than control males, although with no change in affiliative behavior. However, post-pairing, during the resident intruder test, IN OXT males did not differ from control males in contact aggression. During the paternal care test, IN OXT males were quicker to approach their pups than control males but did not differ in vocalizations produced, unlike our previous research demonstrating an effect on vocalizations in females. In summary, during pre-courtship aggression and the paternal care test, IN OXT reduced antisocial behavior; however, during the resident intruder test, IN OXT did not alter antisocial behavior. These data suggest that IN OXT promotes prosocial behavior specifically in social contexts that can lead to affiliation.