Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process
Helminth infection inhibits airway allergic reaction and dendritic cells are involved in the modulation process
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蠕虫感染抑制气道过敏反应，树突状细胞参与调节过程
DOI：
10.1111/j.1365-3024.2009.01161.x
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Yang, X.
中科院分区：
文献类型：
--
作者：
Liu, P.;Li, J.;Yang, X.
P>；以前的几项研究表明，一些蠕虫感染可以抑制过敏反应，但关于日本血吸虫活感染对变态反应性炎症的影响的研究仍然有限。本研究旨在探讨慢性SJ感染对小鼠呼吸道变态反应性炎症的影响及其机制。结果表明，慢性SJ感染抑制了卵清蛋白(OVA)致敏和激发诱导的气道嗜酸性粒细胞增多、黏液产生和抗原特异性IgE反应。细胞因子产生分析显示，慢性SJ感染降低了变应原驱动的白介素4和白介素5的产生，但对干扰素-γ的产生没有明显影响。更重要的是，我们发现过继转移SJ感染小鼠的树突状细胞(DC)显著减少了受体的气道变态反应性炎症，这与IL-4/IL-5的产生显著减少和IL-10的产生增加有关。提示SJ感染可抑制变态反应的发展，DC可能参与了蠕虫感染介导的变态反应性炎症的调节过程。
P>Several previous studies have demonstrated that some helminth infections can inhibit allergic reactions, but the examination on the effect of live Schistosoma japonicum (SJ) infection on allergic inflammation remains limited. The aim of this study was to examine the effect and mechanism of chronic SJ infection on airway allergic inflammation in a murine model. The data showed that chronic SJ infection suppressed airway eosinophilia, mucus production and antigen-specific IgE responses induced by ovalbumin (OVA) sensitization and challenge. Cytokine production analysis showed that chronic SJ infection reduced allergen-driven interleukin (IL)-4 and IL-5 production, but had no significant effect on IFN-gamma production. More importantly, we found that the adoptive transfer of dendritic cells (DCs) from SJ-infected mice dramatically decreased airway allergic inflammation in the recipients, which was associated with significant decrease of IL-4/IL-5 production and increase of IL-10 production. The results suggest that SJ infection may inhibit the development of allergy and that DCs may be involved in the process of helminth infection-mediated modulation of allergic inflammation.