Prefrontal cortex asymmetry for memory encoding of words and abstract shapes
Prefrontal cortex asymmetry for memory encoding of words and abstract shapes
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DOI：
10.1093/cercor/bhh002
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发表时间：
2004-04-01
期刊：
影响因子：
3.7
通讯作者：
Cohen, LG
中科院分区：
文献类型：
--
作者：
Floel, A;Poeppel, D;Cohen, LG
以前的工作表明，前额叶皮质(PFC)对成功编码的贡献取决于刺激材料。在这里，我们测试了这样一种假设，即对单词的编码优先涉及左侧PFC，而对非语言项目(抽象形状)的编码依赖于右侧PFC。我们使用了一种实验设计，评估了相同健康志愿者对单词和抽象形状的编码。通过经颅磁刺激(TMS)，在受试者记忆语言和非语言项目的同时，诱发左侧或右侧PFC的一过性虚拟损害。我们发现，左侧PFC刺激干扰了语言材料的编码，而右侧PFC刺激破坏了非语言材料的编码。这些结果表明，前额叶对言语和非言语记忆编码的贡献存在功能相关的偏侧化。
Previous work suggested a differential contribution of prefrontal cortex (PFC) to successful encoding depending on the stimulus material. Here, we tested the hypothesis that encoding of words preferentially involves the left PFC, while encoding of nonverbal items (abstract shapes) relies on the right PFC. We used an experimental design that evaluated encoding of both words and abstract shapes in the same healthy volunteers. A transient virtual lesion of the left or the right PFC was elicited with transcranial magnetic stimulation (TMS) while subjects memorized verbal and nonverbal items. We found that encoding of verbal material was disrupted by left PFC stimulation, whereas encoding of nonverbal material was disrupted by right PFC stimulation. These results demonstrate a functionally relevant lateralization of prefrontal contribution for verbal and nonverbal memory encoding.