Antimüllerian hormone and leukocyte aging markers in the Coronary Artery Risk Development in Young Adults study.
Antimüllerian hormone and leukocyte aging markers in the Coronary Artery Risk Development in Young Adults study.
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抗苗勒管激素和白细胞老化标记物在年轻成人冠状动脉风险发展研究中的应用
DOI：
10.1016/j.fertnstert.2022.03.021
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发表时间：
2022-07
影响因子：
6.7
通讯作者：
Wellons, Melissa F.
中科院分区：
文献类型：
--
作者：
Kim, Catherine;Puterman, Eli;Hou, Lifang;Slaughter, James C.;Terry, James G.;Wellons, Melissa F.
研究血清抗苗勒管激素（AMH）指示的绝经前生育年龄是否与白细胞衰老生物标志物相关。前瞻性队列分析年轻人冠状动脉危险因素研究（CARDIA），一项基于人群的研究，研究对象为黑人和白色成年绝经前女性，在检查第15年时测量血清AMH以及白细胞老化标志物。考试年15、20和25时的端粒长度、线粒体DNA拷贝数以及内在和外在表观遗传年龄加速，以及考试年之间的变化。女性年龄40.2（SD 3.7）岁，在考试年15，当AMH和端粒长度和线粒体DNA拷贝数的初始措施（n=386），和表观遗传年龄加速发生。在调整了年龄、种族和吸烟史后，第15年检查时AMH四分位数与第15年、第25年检查时的端粒长度或这些年之间的端粒长度变化、第15年、第25年检查时的线粒体DNA拷贝数或这些年之间的变化、第15年、第20年检查时的内在表观遗传年龄加速或这些年之间的变化无关。与最低AMH四分位数的女性相比，第二AMH四分位数的女性具有更快的外在表观遗传年龄加速（β系数1.84，95%置信区间0.20，3.49）。在基于人群的队列研究中，AMH与白细胞端粒长度、线粒体DNA拷贝数或内在表观遗传年龄加速无关。
To examine whether premenopausal reproductive age, as indicated by serum anti-Müllerian hormone (AMH), is associated with leukocyte aging biomarkers. Prospective cohort analysis The Coronary Artery Risk Factors in Young Adults Study (CARDIA), a population-based study of black and white adults Premenopausal women with serum AMH measures at exam year 15 as well as leukocyte aging markers. Telomere length, mitochondrial DNA copy number, and intrinsic and extrinsic epigenetic age acceleration at exam years 15, 20 and 25, as well as change between exam years. Women were aged 40.2 (SD 3.7) years of age at exam year 15, when AMH and initial measures of telomere length and mitochondrial DNA copy number (n=386), and epigenetic age acceleration occurred. After adjustment for chronologic age, race, and smoking history, AMH quartile at exam year 15 was not associated with telomere length at exam year 15, 25, or telomere length change between these years; mitochondrial DNA copy number at exam year 15, 25, or change between these years, or intrinsic epigenetic age acceleration at exam year 15, 20, or change between these years. Women in the 2nd AMH quartile had faster extrinsic epigenetic age acceleration compared to women in the lowest AMH quartile (beta-coefficient 1.84, 95% confidence interval 0.20, 3.49). In a population-based cohort, AMH did not have associations with leukocyte telomere length, mitochondrial DNA copy number, or intrinsic epigenetic age acceleration.
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影响因子：
16
作者：
Hannum, Gregory;Guinney, Justin;Zhao, Ling;Zhang, Li;Hughes, Guy;Sadda, SriniVas;Klotzle, Brandy;Bibikova, Marina;Fan, Jian-Bing;Gao, Yuan;Deconde, Rob;Chen, Menzies;Rajapakse, Indika;Friend, Stephen;Ideker, Trey;Zhang, Kang
通讯作者：
Zhang, Kang
影响因子：
3.7
作者：
Bonomi M;Somigliana E;Cacciatore C;Busnelli M;Rossetti R;Bonetti S;Paffoni A;Mari D;Ragni G;Persani L;Italian Network for the study of Ovarian Dysfunctions
通讯作者：
Italian Network for the study of Ovarian Dysfunctions
影响因子：
5.3
作者：
Mengel-From, Jonas;Thinggaard, Mikael;Dalgard, Christine;Kyvik, Kirsten Ohm;Christensen, Kaare;Christiansen, Lene
通讯作者：
Christiansen, Lene
影响因子：
37.8
作者：
de Kat, Annelien C.;Verschuren, W. Monique;van der Schouw, Yvonne T.
通讯作者：
van der Schouw, Yvonne T.
影响因子：
6.1
作者：
Liu, Yifan;Han, Ming;Yao, Yuanqing
通讯作者：
Yao, Yuanqing