Toward functional neurobehavioral assessment of mood and anxiety.
Toward functional neurobehavioral assessment of mood and anxiety.
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对情绪和焦虑进行功能性神经行为评估。
DOI：
10.1109/iembs.2009.5332809
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Chiu,PearlH
中科院分区：
文献类型：
--
作者：
Lindsey,LaRaun;King-Casas,Brooks;Brovko,Julie;Chiu,PearlH
情绪和焦虑障碍会带来显著的个人和财政成本。目前的治疗努力仅显示出中等疗效，并且对那些对特定治疗方案有反应的患者的特征知之甚少。缺乏症状严重程度的客观描述和疾病结局的可靠预测因素导致诊断和治疗成功率有限。在这里，我们已经开始开发一个规范的神经行为数据库的反应，情感刺激相结合的功能磁共振成像（fMRI），与全面的行为评估和定量分析的神经反应标准的情绪线索。这些数据揭示了两组具有相似的低自我报告抑郁和焦虑的人群之间强大而独特的神经模式，以及一组具有高抑郁和焦虑评分的人群。这和相关的策略可用于识别与精神疾病和韧性相关的隐性表型。
Mood and anxiety disorders confer marked personal and fiscal cost. Current therapeutic efforts show only moderate efficacy, and little is known about the characteristics of those who respond to specific treatment regimens. The lack of objective descriptors of symptom severity and reliable predictors of illness outcome contributes to limited diagnostic and treatment success. Here, we have begun to develop a normative neurobehavioral database of responses to affective stimuli by combining functional magnetic resonance imaging (fMRI), with comprehensive behavioral assessment and quantitative analyses of neural responses to standard emotional cues. These data reveal robust and distinct neural patterns between two groups with similar low self-reported depression and anxiety, and one group with high depression and anxiety scores. This and related strategies may be used to identify covert phenotypes associated with psychiatric illness and resilience.