Growth and recurrence of colorectal polyps: A double-blind 3-year intervention with calcium and antioxidants
Growth and recurrence of colorectal polyps: A double-blind 3-year intervention with calcium and antioxidants
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DOI：
10.1159/000007480
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发表时间：
1998-03-01
期刊：
影响因子：
3.2
通讯作者：
Osnes, M
中科院分区：
文献类型：
--
作者：
Hofstad, B;Almendingen, K;Osnes, M
背景：膳食钙和抗氧化剂已被建议作为预防结直肠癌的保护剂。这得到了动物实验研究、病例对照和队列研究的支持。材料和方法：在一项结直肠腺瘤和结直肠癌发生中期的前瞻性干预研究中，116 名患有息肉的患者每天接受安慰剂对照的混合物，其中含有 15 mg β-胡萝卜素、150 mg 维生素 C、75 mg 维生素 E、101 μg 硒和 1.6 g 碳酸盐钙，为期 3 年，并每年进行结肠镜随访，以测试该混合物是否能够发挥作用。以减少息肉生长或复发。所有息肉
Background: Dietary calcium and antioxidants have been suggested as protective agents against colorectal cancer. This has been supported by animal experimental studies, case control and cohort studies. Materials and Methods: In a prospective intervention study of colorectal adenomas, and intermediary stage in colorectal carcinogenesis, 116 polyp-bearing patients received a placebo-controlled daily mixture of beta-carotene 15 mg, vitamin C 150 mg, vitamin E 75 mg, selenium 101 mu g, and calcium (1.6 g daily) as carbonate for a period of 3 years with annual colonoscopic follow-up to test if the mixture was able to reduce polyp growth or recurrence. All polyps of