The interplay between childhood trauma, cognitive biases, and cannabis use on the risk of psychosis in nonclinical young adults in Poland
The interplay between childhood trauma, cognitive biases, and cannabis use on the risk of psychosis in nonclinical young adults in Poland
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DOI：
10.1192/j.eurpsy.2020.31
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发表时间：
2020-01-01
影响因子：
7.8
通讯作者：
Gaweda, Lukasz
中科院分区：
文献类型：
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作者：
Frydecka, Dorota;Misiak, Blazej;Gaweda, Lukasz
背景资料。童年创伤事件是精神病样经历(PLE)的危险因素。然而，解释创伤如何促进PLES发展的机制还不完全清楚。在我们的研究中，我们调查了大麻使用和认知偏差是否在早期创伤和PLE之间起中介作用。从一般人群中招募了6772名年轻人(年龄26.6岁+/-4.7岁，2181名男性和3433名女性)参加了一项在线调查。我们排除了1158名自我报告的终生精神障碍患者。在线调查包括以下问卷中的精选项目：创伤体验检查表(TEC，3个条目)、儿童护理和虐待体验问卷(CECA.Q，3个条目)、大麻问题问卷(CPQ，10个条目)、达沃斯认知偏向评定量表(DACOBS-18，9个条目)和前驱问卷-16(PQ-16)。对不同类型的创伤经历(情感、身体和性虐待以及情感忽视)进行中介分析。我们的结果显示，童年创伤的任何时间都与较高的大麻使用(CPQ)、认知偏差(DACOBS)和PLES(PQ-16)得分显著相关(p<；0.001)。我们发现童年创伤对PLE的直接影响以及通过大麻使用和认知偏差介导的显著间接影响。所有测试特定童年逆境影响的模型都显示了类似的结果。系列中介模型解释的PQ-16得分的变异百分比在32.8-34.2%之间，这取决于儿童创伤的类别。在非临床青壮年人群中，大麻使用和认知偏差在儿童创伤事件和PLES发展之间的关系中起着重要的中介作用。
Background. Childhood traumatic events are risk factors for psychotic-like experiences (PLEs). However, the mechanisms explaining how trauma may contribute to the development of PLEs are not fully understood. In our study, we investigated whether cannabis use and cognitive biases mediate the relationship between early trauma and PLEs.Methods. A total sample of 6,772 young adults (age 26.6 +/- 4.7, 2,181 male and 3,433 female) was recruited from the general population to participate in an online survey. We excluded 1,158 individuals due to a self-reported lifetime diagnosis of any mental disorder. The online survey included selected items from the following questionnaires: Traumatic Experience Checklist (TEC, 3 items), Childhood Experience of Care and Abuse Questionnaire (CECA.Q, 3 items), Cannabis Problems Questionnaire (CPQ, 10 items), Davos Assessment of Cognitive Biases Scale (DACOBS-18, 9 items), and Prodromal Questionnaire-16 (PQ-16). Mediation analyses were performed with respect to different categories of traumatic experiences (emotional, physical and sexual abuse as well as emotional neglect).Results. Our results showed significant associations of any time of childhood trauma with higher scores of cannabis use (CPQ), cognitive biases (DACOBS), and PLEs (PQ-16) (p < 0.001). We found a direct effect of childhood trauma on PLEs as well as significant indirect effect mediated through cannabis use and cognitive biases. All models tested for the effects of specific childhood adversities revealed similar results. The percentage of variance in PQ-16 scores explained by serial mediation models varied between 32.8 and 34.2% depending on childhood trauma category.Conclusion. Cannabis use and cognitive biases play an important mediating role in the relationship between childhood traumatic events and the development of PLEs in a nonclinical young adult population.