An 8pi electron electrocyclization leading to a 9,19-methano-bridged analogue of 1 alpha,25-dihydroxyvitamin D3.
An 8pi electron electrocyclization leading to a 9,19-methano-bridged analogue of 1 alpha,25-dihydroxyvitamin D3.
复制标题
8pi 电子电环化产生 1 α,25-二羟基维生素 D3 的 9,19-甲桥桥类似物。
DOI：
10.1021/ol020017h
复制
发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Okamura,WilliamH
中科院分区：
文献类型：
--
作者：
Hayashi,Rena;Fernández,Susana;Okamura,WilliamH
Lindlar semihydrogenation of a vitamin D type trienyne leads spontaneously to 9α,19-methano-1α,25-dihydroxyvitamin D3. The intermediate tetraene resulting from the reduction undergoes a rapid, stereoselective 8π electron electrocyclization affording a novel steroid containing a linearly fused ABC (six-eight-six) 1,3,5-cyclooctatriene carbon framework.
