Poly(A)-binding proteins are required for diverse biological processes in metazoans.
Poly(A)-binding proteins are required for diverse biological processes in metazoans.
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DOI：
10.1042/bst20140111
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发表时间：
2014-08
影响因子：
3.9
通讯作者：
Gray NK
中科院分区：
文献类型：
--
作者：
Smith RW;Blee TK;Gray NK
PABP [poly（A）-binding proteins]与真核生物mRNA的poly（A）尾结合，在从酵母到人类的物种中是保守的。原型细胞质成员PABP 1是一种多功能RNA结合蛋白，在全局和mRNA特异性翻译和稳定性中发挥作用，与作为细胞质中mRNA命运的中心调节因子的功能一致。对其他家族成员的分子功能有更有限的了解。然而，在整个生物体中破坏PABP功能的后果尚不清楚，特别是在脊椎动物中，在哺乳动物中更是如此。在本综述中，我们讨论了当前和新出现的知识与PABP家族成员的功能，在整个动物研究，虽然不完整，已经强调其生物学的重要性，并强调需要在这一领域进一步深入研究。
PABPs [poly(A)-binding proteins] bind to the poly(A) tail of eukaryotic mRNAs and are conserved in species ranging from yeast to human. The prototypical cytoplasmic member, PABP1, is a multifunctional RNA-binding protein with roles in global and mRNA-specific translation and stability, consistent with a function as a central regulator of mRNA fate in the cytoplasm. More limited insight into the molecular functions of other family members is available. However, the consequences of disrupting PABP function in whole organisms is less clear, particularly in vertebrates, and even more so in mammals. In the present review, we discuss current and emerging knowledge with respect to the functions of PABP family members in whole animal studies which, although incomplete, already underlines their biological importance and highlights the need for further intensive research in this area.