Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats.
Influence of salt loading on the cardiac and renal preproendothelin-1 mRNA expression in stroke-prone spontaneously hypertensive rats.
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盐负荷对脑卒中易发性高血压大鼠心脏和肾脏前内皮素原 1 mRNA 表达的影响。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
T. Godfraind
中科院分区：
文献类型：
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作者：
O. Feron;S. Salomone;T. Godfraind
内皮素-1是一种有效的血管活性肽，可能通过其自分泌/旁分泌作用调节血管阻力。我们研究了盐负荷对中风易发自发性高血压大鼠肾脏和心脏内皮素-1生成的影响。结果表明，饮食盐摄入量没有改变收缩压和肾脏内皮素-1前原mRNA的表达，但增加了心脏内皮素-1基因转录物的表达，并伴有心室肥厚。
Endothelin-1 is a potent vasoactive peptide which may play a role in the regulation of vascular resistance through its autocrine/paracrine effects. We have investigated the influence of salt loading on the renal and cardiac production of endothelin-1 in stroke prone spontaneously hypertensive rats, a classical model of hypertension. The results show that the dietary salt intake did not change systolic blood pressure nor the renal expression of the preproendothelin-1 mRNA but increased cardiac expression of the endothelin-1 gene transcript and a concomitant ventricular hypertrophy.