Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
Obesity and cancer: Mendelian randomization approach utilizing the FTO genotype
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DOI：
10.1093/ije/dyp162
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发表时间：
2009-08-01
影响因子：
7.7
通讯作者：
Smith, George Davey
中科院分区：
文献类型：
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作者：
Brennan, Paul;McKay, James;Smith, George Davey
方法采用孟德尔随机化方法，对7000例肺癌、肾癌和上呼吸消化道癌患者的FTO基因变异进行分析。结果FTO基因A等位基因与肺癌发病风险的降低相关，而FTO基因A等位基因与肺癌发病风险的降低相关（等位基因优势比（OR）= 0.92，95%置信区间（CI）0.84-1.00）。它也与一个弱的肾癌的风险增加，这是更明显的50岁之前（OR = 1.44，CI 1.09-1.90）。结论我们的研究结果突出了潜在的遗传变异作为一个无混淆的标记的环境可改变的因素，并提供了可能获得的估计肥胖的因果关系。然而，需要比这里研究的样本量大得多的样本量才能精确地进行这项工作。
Methods To avoid these biases we used a Mendelian randomization approach incorporating an analysis of variants in the FTO gene that are strongly associated with BMI levels among 7000 subjects from a study of lung, kidney and upper-aerodigestive cancer.Results The FTO A allele which is linked with increased BMI was associated with a decreased risk of lung cancer (allelic odds ratio (OR) = 0.92, 95% confidence interval (CI) 0.84-1.00). It was also associated with a weak increased risk of kidney cancer, which was more apparent before the age of 50 (OR = 1.44, CI 1.09-1.90).Conclusion Our results highlight the potential for genetic variation to act as an unconfounded marker of environmentally modifiable factors, and offer the potential to obtain estimates of the causal effect of obesity. However, far larger sample sizes than studied here will be required to undertake this with precision.