Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection.
Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection.
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DOI：
10.1016/j.antiviral.2012.09.013
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发表时间：
2012-12
影响因子：
7.6
通讯作者：
Yen HL
中科院分区：
文献类型：
--
作者：
Lee SM;Yen HL
►针对流感复制机制的新型抗病毒化合物正在开发中。唾液酸酶和蛋白酶抑制剂可在宿主水平阻断病毒进入。将针对病毒-宿主相互作用和宿主细胞机制的策略作为治疗选择。流感流行和大流行是对人类健康的持续威胁。抗病毒药物的应用提供了对流感病毒感染的立即和直接的控制。目前，管理流感患者的主要策略是通过靶向对病毒复制至关重要的保守病毒蛋白。两类常规抗病毒药物，M2离子通道阻断剂和神经氨酸酶抑制剂，经常使用。近年来，对这两类药物的耐药性日益增加，已成为一个主要的公共卫生问题，突出表明迫切需要开发替代治疗方法。靶向病毒复制机制的新型抗病毒化合物或生物分子正在开发中，使用的方法包括高通量小分子筛选平台和基于结构的设计。为了应对流感病毒感染，宿主细胞机制被触发以防御入侵者。与此同时，病毒作为专性细胞内病原体已经进化为利用细胞应答来支持其有效复制，包括拮抗宿主I型干扰素应答以及在复制周期的不同阶段激活特定细胞途径。许多研究强调了靶向病毒-宿主相互作用和宿主细胞机制以开发新的治疗方案的可能性。这篇综述旨在概述针对病毒和宿主管理流感的当前和新概念。
► Novel antiviral compounds targeting influenza replication mechanism are under development. ► Sialidase and protease inhibitors may block viral entry at the host level. ► Strategies targeting virus–host interactions and host cellular mechanisms as treatment options. Influenza epidemics and pandemics are constant threats to human health. The application of antiviral drugs provides an immediate and direct control of influenza virus infection. At present, the major strategy for managing patients with influenza is through targeting conserved viral proteins critical for viral replication. Two classes of conventional antiviral drugs, the M2 ion channel blockers and the neuraminidase inhibitors, are frequently used. In recent years, increasing levels of resistance to both drug classes has become a major public health concern, highlighting the urgent need for the development of alternative treatments. Novel classes of antiviral compounds or biomolecules targeting viral replication mechanism are under development, using approaches including high-throughput small-molecule screening platforms and structure-based designs. In response to influenza virus infection, host cellular mechanisms are triggered to defend against the invaders. At the same time, viruses as obligate intracellular pathogens have evolved to exploit cellular responses in support of their efficient replication, including antagonizing the host type I interferon response as well as activation of specific cellular pathways at different stages of the replication cycle. Numerous studies have highlighted the possibility of targeting virus–host interactions and host cellular mechanisms to develop new treatment regimens. This review aims to give an overview of current and novel concepts targeting the virus and the host for managing influenza.
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影响因子：
2.9
作者：
BODIAN, DL;YAMASAKI, RB;KUNTZ, ID
通讯作者：
KUNTZ, ID
DOI：
10.1126/science.1187816
发表时间：
2010-06-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bloom JD;Gong LI;Baltimore D
通讯作者：
Baltimore D
影响因子：
4.9
作者：
Chan, Renee W. Y.;Chan, Michael C. W.;Nicholls, John M.
通讯作者：
Nicholls, John M.
影响因子：
2.9
作者：
Balannik, Victoria;Wang, Jun;Pinto, Lawrence H.
通讯作者：
Pinto, Lawrence H.
影响因子：
82.9
作者：
Chen, WS;Calvo, PA;Yewdell, JW
通讯作者：
Yewdell, JW