AMYGDALOID PROJECTIONS TO THE FRONTAL-CORTEX AND THE STRIATUM IN THE RAT
AMYGDALOID PROJECTIONS TO THE FRONTAL-CORTEX AND THE STRIATUM IN THE RAT
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DOI：
10.1002/cne.902980104
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发表时间：
1990-08-01
影响因子：
2.5
通讯作者：
KITAI, ST
中科院分区：
文献类型：
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作者：
KITA, H;KITAI, ST
用菜豆-亮氨酸凝集素(PHA-L)顺行追踪技术研究了大鼠杏仁基底外侧核(BLA)向额叶皮质和纹状体的投射。将PHA-L注射到BLA的吻侧部分，在鼻裂背侧以及无颗粒皮质的外侧和内侧，出现了密集的纤维外周标记。将PHA-L注射到大脑白质尾侧部分，在额叶皮质内侧表面产生了密集的纤维标记。在大多数皮质区域，标记纤维主要分布在I层和II层的深部和V层和VI层的较重的带中。将PHA-L注射到BLA的吻侧，在嗅结节、伏核的吻侧和尾外侧部以及尾壳核的大片区域内，出现了密集的带突起的标记纤维。尾壳核的标记区包括旋转腹侧区、中央区、前连合尾侧区和苍白球背侧侧区。将PHA-L注射到尾侧BLA，在尾壳核吻内侧面向侧脑室的最内侧区域、伏隔核内侧部分和外侧隔产生纤维标记。在轮状腹侧纹状体，PHA-L标记纤维选择性地支配含有丰富生长抑素免疫反应纤维的基质小室。隔室分离在尾侧尾壳核和伏隔核中较不明显。电子显微镜观察发现，在纹状体内，PHA-L标记的胞体内含有丰富的小而圆的囊泡。这些突触与纹状体神经元的树突形成非对称性突触。
Projections from the basolateral nucleus of the amygdala (BLA) to the frontal cortex and the striatum were studied by using Phaseolus vulgaris-leucoagglutinin (PHA-L) anterograde tracing technique in the rat. PHA-L injections into the rostral part of the BLA resulted in a dense labeling of fibers with boutons in the dorsal bank of the rhinal fissure and in the lateral and the medial agranular cortex. PHA-L injections into the caudal part of the BLA produced a dense labeling of fibers in the medial surface of the frontal cortex. In most of the cortical regions, labeled fibers were predominantly distributed in two bands: one in the deep part of layers I and II and the other, heavier band, in layers V and VI. PHA-L injections into the rostral BLA resulted in a dense labeling of fibers with boutons in the olfactory tubercle, the rostral and caudolateral portion of the nucleus accumbens, and a large region of the caudate-putamen. The labeled area of the caudate-putamen included the rostroventral area, the central area, and the area caudal to the anterior commissure and dorsal and lateral to the globus pallidus. PHA-L injections into the caudal BLA produced fiber labeling in the most rostromedial area of the caudate-putamen facing the lateral ventricle, the medial portion of the nucleus accumbens, and the lateral septum. In the rostroventral striatum, PHA-L-labeled fibers selectively innervated the matrix compartment that contains abundant somatostatin-immunoreactive fibers. Compartmental segregation was less clear in the caudodorsolateral caudate-putamen and in the nucleus accumbens. Electron microscopy revealed that PHA-L-labeled boutons in the striatum contained abundant, small, round vesicles. These boutons formed asymmetrical synapses with dendritic spines of striatal neurons.