Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis
Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis
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卵巢上皮癌合并盆腔子宫内膜异位症的临床分析
DOI：
10.1016/j.ajog.2012.12.004
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发表时间：
2013-05-01
影响因子：
9.8
通讯作者：
Wu, Ming
中科院分区：
文献类型：
--
作者：
Wang, Shu;Qiu, Lin;Wu, Ming
目的：研究设计：回顾性分析2011 - 03/2012 - 03北京协和医院收治的226例卵巢上皮性癌患者的病历资料。结果：与非子宫内膜异位症相关性卵巢癌相比，子宫内膜异位症相关性卵巢癌患者：（1）诊断为上皮性卵巢癌时年龄较轻，绝经前的可能性较大（P = 0.03和0.005）;（2）术前血清Ca 125水平较低（平均值：122.9 vs 1377.5 U/mL，P < .001），更可能显示正常的Ca 125水平（3）早期发现（I期，P < .001）;（4）组织学亚型分布完全不同（透明细胞癌和类透明细胞癌的显著过度表达）。因此，子宫内膜异位症相关性卵巢癌患者在许多重要的临床和生物学特征上不同于非子宫内膜异位症相关性卵巢癌患者。
OBJECTIVES: To explore the differences between women with endometiosis associated ovarian cancer and typical epithelial ovarian cancer.STUDY DESIGN: The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union Medical College Hospital between March 2011 and March 2012 were reviewed. Histology evaluation determined endometiosis associated ovarian cancer (n = 17) or nonendometiosis associated ovarian cancer (n = 209).RESULTS: Compared with nonendometiosis associated ovarian cancer, patients with endometiosis associated ovarian cancer were proved: (1) to be younger and more likely to be premenopausal at diagnosis of epithelial ovarian cancer (P = .03 and .005, respectively); (2) to have lower preoperative serum level of Ca125 (mean: 122.9 vs 1377.5 U/mL, P < .001) and more likely to display normal Ca125 level (P < .001); (3) to be identified at the earlier stage (stage I, P < .001); (4) to have completely different distribution of histological subtypes (significant overrepresentation of clear cell and endometrioid carcinoma).CONCLUSION: As such, patients with endometiosis associated ovarian cancer differ from nonendometiosis associated ovarian cancer in many of their critical clinical and biologic characteristics.