Facilitation by drug states does not depend on acquired excitatory strength
Facilitation by drug states does not depend on acquired excitatory strength
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DOI：
10.1016/j.bbr.2006.10.015
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发表时间：
2007-01-25
影响因子：
2.7
通讯作者：
Bevins, Rick A.
中科院分区：
文献类型：
--
作者：
Palmatier, Matthew I.;Bevins, Rick A.
三个实验检查了当药物状态用作蔗糖递送的条件刺激（CS）或作为离散CS（例如，15-s光照）和蔗糖。一些条件反射模型预测，药物状态将促进条件反应（CR）的基础上与蔗糖的关联，无论药物是作为一个CS或作为一个促进剂训练。如果是这样的话，重复出现单独的药物状态（药物消退）应该会降低这两种情况下的CR。尼古丁（0.4 mg/kg）、安非他明（AMP，1 mg/kg）和利血平（CDP，5 mg/kg）促进了对离散CS的目标追踪条件反应;然而，AMP和CDP在没有插入刺激的情况下没有引起可靠的反应，这表明这些药物状态和蔗糖之间的关联并不表示为预期的食物寻求（目标追踪）。重复呈现每种药物状态单独没有破坏尼古丁，安非他明或CDP的促进作用;这表明药物状态没有促进基于与蔗糖的直接关联的目标跟踪，后一个发现暗示了一种高阶或非关联机制，用于促进药物状态在巴甫洛夫辨别任务中的预期食物寻求。(c)2006 Elsevier B. V.保留所有权利。
Three experiments examined the effects of drug-extinction when a drug state served as a conditional stimulus (CS) for sucrose delivery or as a positive feature for pairings between a discrete CS (e.g., 15-s light-on) and sucrose. Some conditioning models predict that drug state will facilitate the conditional response (CR) based on an association with sucrose whether the drug is trained as a CS or as a facilitator. If so, repeated presentation of the drug state alone (drug-extinction) should decrease the CR in both situations. Nicotine (0.4 mg/kg), amphetamine (AMP, I mg/kg), and chlordiazepoxide (CDP, 5 mg/kg) facilitated a goal tracking conditioned response to the discrete CS; however, AMP and CDP did not evoke reliable responding without an interposed stimulus, suggesting that associations between these drug states and sucrose are not expressed as anticipatory food seeking (goal tracking). Repeated presentation of each drug state alone did not disrupt facilitation by nicotine, amphetamine, or CDP; suggesting that the drug states did not facilitate goal tracking based on a direct association with sucrose, This latter finding implicates a higher-order or non-associative mechanism for facilitation of anticipatory food seeking by drug states in this Pavlovian discrimination task. (c) 2006 Elsevier B.V. All rights reserved.