The cutaneous vasoconstrictor response in lower extremities during whole-body and local skin cooling in young women with a cold constitution
The cutaneous vasoconstrictor response in lower extremities during whole-body and local skin cooling in young women with a cold constitution
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DOI：
10.1007/s12576-015-0378-3
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发表时间：
2015-09-01
影响因子：
2.3
通讯作者：
Yamazaki, Fumio
中科院分区：
文献类型：
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作者：
Yamazaki, Fumio
为了阐明寒冷体质个体皮肤血流（SkBF）的热控制特征，我们研究了抱怨寒冷的年轻女性（C组）和没有遭受寒冷的年轻女性（N组）在全身和局部皮肤冷却期间小腿和足背的皮肤血管收缩反应。在全身皮肤冷却过程中，C组的足背血管收缩剂敏感性高于N组，但小腿的血管收缩剂敏感性则没有。C组也表现出更大的血管收缩反应，在足背，但不是在小腿，在局部皮肤冷却和去甲肾上腺素的离子电渗应用。这些研究结果表明，C组拥有一个特定的SkBF控制系统，其特点是更高的肾上腺素敏感性更大的皮肤血管收缩在远端部分的下肢在寒冷的暴露。
To clarify the characteristics of the thermal control of skin blood flow (SkBF) in individuals with a cold constitution, we examined the cutaneous vasoconstrictor responses in the calf and dorsal foot during whole-body and local skin cooling in young women complaining of chilliness (C group) and young women not suffering from it (N group). During whole-body skin cooling, the vasoconstrictor sensitivity in the dorsal foot, but not in the calf, was greater in the C group than in the N group. The C group also showed greater vasoconstrictor responses in the dorsal foot, but not in the calf, during local skin cooling and the iontophoretic application of norepinephrine. These findings suggest that the C group possesses a specific SkBF controlling system that is characterized by higher adrenergic sensitivity for greater cutaneous vasoconstriction in the distal portion of the lower extremities during cold exposure.