Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease.
Molecular imaging of neuropsychiatric symptoms in Alzheimer's and Parkinson's disease.
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DOI：
10.1016/j.neubiorev.2014.11.010
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发表时间：
2015-02
影响因子：
8.2
通讯作者：
Smith GS
中科院分区：
文献类型：
--
作者：
Hirao K;Pontone GM;Smith GS
Neuropsychiatric symptoms (NPS) are very common in neurodegenerative diseases and are a major contributor to disability and caregiver burden. There is accumulating evidence that NPS may be a prodrome of neurodegenerative diseases and are associated with functional decline. The medications used to treat these symptoms in younger patients are not very effective in patients with neurodegenerative disease and may have serious side effects. An understanding of the neurobiology of NPS is critical for the development of more effective intervention strategies. Targeting these symptoms may also have implications for prevention of cognitive or motor decline. Molecular brain imaging represents a bridge between basic and clinical observations and provides many opportunities for translation from animal models and human post-mortem studies to in vivo human studies. Molecular brain imaging studies in Alzheimer’s disease (AD) and Parkinson’s disease (PD) are reviewed with a primary focus on positron emission tomography studies of NPS. Future directions for the field of molecular imaging in AD and PD to understand the neurobiology of NPS will be discussed.
