Effects of hair treatment on hair mercury—The best biomarker of methylmercury exposure?
Effects of hair treatment on hair mercury—The best biomarker of methylmercury exposure?
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DOI：
10.1007/bf02897712
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发表时间：
2005-07
影响因子：
4.7
通讯作者：
M. Dakeishi;Kunihiko Nakai;M. Sakamoto;Toyoto Iwata;Keita Suzuki;Xiao-jie Liu;Tomoko Ohno;T. Kurosawa;H. Satoh;K. Murata
中科院分区：
文献类型：
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作者：
M. Dakeishi;Kunihiko Nakai;M. Sakamoto;Toyoto Iwata;Keita Suzuki;Xiao-jie Liu;Tomoko Ohno;T. Kurosawa;H. Satoh;K. Murata
目的暴露分类错误是获得准确剂量-反应关系的主要障碍。为了解决这个问题，方法对327名24-49岁的日本女性进行了一项横断面研究，以确定头发汞水平，并使用食物频率问卷估计每日海鲜汞摄入量。结果女性头发汞水平和每日汞摄入量范围为0.11 ~ 6.86（中位数1.63）μg/g和0.77 - 144.9（中位数15.0）μg/d。发汞与日汞摄入量呈正相关（P<0.001）。当根据人工烫发、染发/染发、居住地（非捕鱼区和捕鱼区）和工作状况将妇女分为两个亚组时，观察到仅使用人工烫发和未使用人工烫发的妇女的头发汞水平存在显著差异（p<0.001）。多元回归分析显示，对数转换的发汞水平与对数转换的每日汞摄入量（标准化回归系数βs=0.307）和人工烫发（βs=-0.276）显著相关，而与染发/染发、居住地、工作状态或年龄无关。永久性头发治疗估计减少头发中的总汞约30%，调整后每日汞摄入量和其他可能的factors.ConclusionsThese研究结果表明，头发汞是不是最好的生物标志物甲基汞暴露时，研究人群包括妇女与人工烫发。
ObjectivesExposure misclassification is a major obstacle to obtain accurate dose-response relationships. In order to solve this problem, the impact of hair treatment on total mercury in hair was assessed in Japanese women.MethodsA cross-sectional study was carried out among 327 women at age 24–49 years to determine hair mercury levels and estimate daily mercury intakes from seafood by using a food frequency questionnaire.ResultsHair mercury levels in the women and daily mercury intake ranged from 0.11 to 6.86 (median 1.63) μg/g and from 0.77 to 144.9 (median 15.0) μg/day, respectively. The hair mercury was positively correlated with the daily mercury intake (p<0.001). When the women were divided into two subgroups based on artificial hair-waving, hair coloring/dyeing, residence (non-fishing and fishing areas), and working status, a significant difference in the hair mercury level was observed between the women with and without artificial hair-waving only (p<0.001). The multiple regression analysis showed that the log-transformed hair mercury level was significantly related to the log-transformed daily mercury intake (standardized regression coefficient βs=0.307) and artificial hair-waving (βs=−0.276); but not to hair coloring/dyeing, residence, working status or age. Permanent hair treatment was estimated to reduce total mercury in hair by approximately 30%, after adjusting for daily mercury intake and other possible factors.ConclusionsThese findings suggest that hair mercury is not the best biomarker of methylmercury exposure when a study population includes women with artificial hair-waving.