The “nootropic” approach to the pharmacology of the integrative activity of the brain 1, 2
The “nootropic” approach to the pharmacology of the integrative activity of the brain 1, 2
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大脑综合活动的药理学“促智”方法 1, 2
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
C. Giurgea
中科院分区：
文献类型：
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作者：
C. Giurgea
大脑的整合活动尤其与中枢神经系统的远端脑区水平有关。影响学习和记忆的药物通常会干扰网状或边缘系统，它们要么是兴奋剂，要么是镇静剂。相比之下，吡拉西坦（U C B 6215）是一种有毒化合物，其剂量高达g/kg，不会干扰自主神经功能、一般行为、清醒水平、边缘系统等。然而，在mg/kg等剂量下，它可以改善几种学习和记忆能力，防止实验性遗忘药物，促进严重缺氧后脑电图恢复，并促进半球间转移（经胼胝体诱发电位和学习行为）。根据特定的神经药理学以及可用的生化和人类临床相关性进行了讨论，以强调该化合物对端脑综合机制的选择性。吡拉西坦是一种新的精神药物类别的第一名，其中提出了“促精神药”一词。
The integrative activity of the brain is particularly related to the telencephalic level of CNS. Drugs affecting learning and memory usually interfere with the reticular or limbic system, and are either stimulants or sedatives. In contrast, Piracetam (U C B 6215) is an atoxic compound which, up to dosages such as g/kg, does not interfere with autonomic functions, general behavior, level of wakefulness, the limbic system, etc. Yet, in dosages such as mg/kg it improves several learning and memory abilities, protects against experimental amnesic agents, facilitates EEG recovery after severe hypoxia and also facilitates interhemispheric transfer (transcallosal evoked potential and learned behavior). Discussion is made on the basis of the particular neuropharmacology as well as on the available biochemical and human clinical correlations to emphasize the selectivity of this compound on telencephalic integrative mechanisms. Piracetam is presented as the first-comer of a new psychotropic class for which the termnootropic is proposed.