Evolution of the facial skin microbiome during puberty in normal and acne skin.
Evolution of the facial skin microbiome during puberty in normal and acne skin.
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正常和痤疮皮肤青春期面部皮肤微生物组的进化。
DOI：
10.1111/jdv.18616
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Nelson,AmandaM
中科院分区：
文献类型：
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作者：
Schneider,AndreaM;Nolan,ZacharyT;Banerjee,Kalins;Paine,AllisonR;Cong,Zhaoyuan;Gettle,SamanthaL;Longenecker,AmyL;Zhan,Xiang;Agak,GeorgeW;Nelson,AmandaM
从婴儿期到成年期，皮肤微生物组的组成各不相同，并在成年期变得最稳定。成年痤疮患者体内的“痤疮微生物群”由痤疮表皮杆菌的特定菌株主导。然而，皮肤微生物群进化的精确时间，痤疮微生物群的发展，以及向毒性的转变。青春期的应激成分是未知的。目的：我们在儿科人群中进行了一项横断面试点研究，以了解青春期皮肤微生物组组成如何以及何时发生变化，以及儿科受试者中是否出现了独特的“痤疮微生物组”。方法48名年龄在7-17岁、有或没有痤疮的志愿者，包括男性和女性，使用Tanner分期标准评估青春期发育。测量皮脂水平，并用无菌棉签在受试者额头上收集皮肤微生物群。DNA测序采用全基因组霰弹枪测序法。结果：微生物多样性在青春期早期（T1‐T2）和晚期（T3‐T5）出现了显著的变化，与面部皮脂分泌增加相一致。c的总体相对丰度。正常皮肤和痤疮皮肤的痤疮素在青春期和个体c时均增加。痤疮菌株受青春期和痤疮存在的独特影响。此外，痤疮微生物组特征与unique相关。痤疮患者在青春期后期出现痤疮成分和代谢活动。这uniqueC。据预测，Acnesstrain组合物会增加卟啉的产生，这可能会导致皮肤炎症。结论青春期发育阶段影响皮肤微生物组组成。随着儿童的成熟，一个独特的痤疮微生物组成出现在那些痤疮。了解青春期和痤疮如何影响微生物群可能支持新的治疗策略来对抗儿科人群中的痤疮。
BackgroundThe composition of the skin microbiome varies from infancy to adulthood and becomes most stable in adulthood. Adult acne patients harbour an ‘acne microbiome’ dominated by specific strains ofCutibacterium acnes.However, the precise timing of skin microbiome evolution, the development of the acne microbiome, and the shift to virulentC. acnesstrain composition during puberty is unknown.ObjectivesWe performed a cross‐sectional pilot study in a paediatric population to understand how and when the skin microbiome composition transitions during puberty and whether a distinct ‘acne microbiome’ emerges in paediatric subjects.MethodsForty‐eight volunteers including males and females, ages 7–17 years, with and without acne were enrolled and evaluated for pubertal development using the Tanner staging criteria. Sebum levels were measured, and skin microbiota were collected by sterile swab on the subject's forehead. DNA was sequenced by whole genome shotgun sequencing.ResultsA significant shift in microbial diversity emerged between early (T1‐T2) and late (T3‐T5) stages of puberty, coinciding with increased sebum production on the face. The overall relative abundance ofC. acnesin both normal and acne skin increased during puberty and individualC. acnesstrains were uniquely affected by pubertal stage and the presence of acne. Further, an acne microbiome signature associated with uniqueC. acnesstrain composition and metabolic activity emerges in late puberty in those with acne. This uniqueC. acnesstrain composition is predicted to have increased porphyrin production, which may contribute to skin inflammation.ConclusionsOur data suggest that the stage of pubertal development influences skin microbiome composition. As children mature, a distinct acne microbiome composition emerges in those with acne. Understanding how both puberty and acne influence the microbiome may support novel therapeutic strategies to combat acne in the paediatric population.