Quantification of myocardial blood flow with 82Rb dynamic PET imaging
Quantification of myocardial blood flow with 82Rb dynamic PET imaging
复制标题
DOI：
10.1007/s00259-007-0478-2
复制
发表时间：
2007-11-01
影响因子：
9.1
通讯作者：
dekemp, Robert A.
中科院分区：
文献类型：
--
作者：
Lortie, Mireille;Beanlands, Rob S. B.;dekemp, Robert A.
目的PET示踪剂Rb-82常用于评价冠状动脉病变的局部灌注缺损。关于用这种示踪剂定量心肌血流量和血流储备的信息有限。本研究的目的是探讨使用的一个房室模型Rb-82动力学的定量心肌bloodflow.Methods 14名健康志愿者进行休息和潘生丁负荷成像与N-13-氨和Rb-82在2周的时间间隔。使用标准二室模型从用N-13-氨测量的时间-活性曲线估计心肌血流量。从用Rb-82测量的时间-活性曲线估计一室模型的摄取参数。为了描述心肌血流量和摄取参数之间的关系，对数据拟合非线性提取函数。然后使用该函数将摄取参数的估计值转换为流量估计值。提取功能与一个独立的数据集，从13名受试者与记录的证据冠状动脉disease（CAD）。结果一室模型描述82 Rb动力学非常好（中位数R-平方=0.98）。用Rb-82获得的流量估计值与用N-13-氨获得的流量估计值具有良好的相关性（r=0.85），并且最佳拟合线与身份线没有显著差异。从CAD的受试者获得的数据证实了估计提取function. Conclusion的有效性，这是可能的，以获得准确的估计心肌血流量和血流储备与Rb-82动力学的一室模型和非线性提取函数。
Purpose The PET tracer Rb-82 is commonly used to evaluate regional perfusion defects for the diagnosis of coronary artery disease. There is limited information on the quantification of myocardial blood flow and flow reserve with this tracer. The goal of this study was to investigate the use of a one-compartment model of Rb-82 kinetics for the quantification of myocardial blood flow.Methods Fourteen healthy volunteers underwent rest and dipyridamole stress imaging with both N-13-ammonia and Rb-82 within a 2-week interval. Myocardial blood flow was estimated from the time-activity curves measured with N-13-ammonia using a standard two-compartment model. The uptake parameter of the one-compartment model was estimated from the time-activity curves measured with Rb-82. To describe the relationship between myocardial blood flow and the uptake parameter, a nonlinear extraction function was fitted to the data. This function was then used to convert estimates of the uptake parameter to flow estimates. The extraction function was validated with an independent data set obtained from 13 subjects with documented evidence of coronary artery disease (CAD).Results The one-compartment model described 82Rb kinetics very well (median R-square=0.98). The flow estimates obtained with Rb-82 were well correlated with those obtained with N-13-ammonia (r=0.85), and the best-fit line did not differ significantly from the identity line. Data obtained from the subjects with CAD confirmed the validity of the estimated extraction function.Conclusion It is possible to obtain accurate estimates of myocardial blood flow and flow reserve with a one-compartment model of Rb-82 kinetics and a nonlinear extraction function.