Circulating tumour necrosis factor receptors 1 and 2 predict contrast-induced nephropathy and progressive renal dysfunction: A prospective cohort study
Circulating tumour necrosis factor receptors 1 and 2 predict contrast-induced nephropathy and progressive renal dysfunction: A prospective cohort study
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DOI：
10.1111/nep.12448
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发表时间：
2015-08-01
期刊：
影响因子：
2.5
通讯作者：
Lee, Jung Pyo
中科院分区：
文献类型：
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作者：
An, Jung Nam;Yoo, Kyung Don;Lee, Jung Pyo
目的对比性肾病(CIN)是医院获得性急性肾损伤的重要原因。对CIN发病机制的准确认识是至关重要的。本研究的目的是评价循环肿瘤坏死因子受体(CTNFR)在CIN中的临床意义。方法2013年5月至2014年2月，在首尔国立大学Boramae医学中心接受冠状动脉造影和/或经皮冠状动脉介入治疗的患者262例。CIN定义为术后48小时内血肌酐升高22.1%/L或25%。结果糖尿病和慢性肾脏病分别占27.5%和17.6%，平均年龄65岁。所有患者都接受了液体治疗，36.3%的患者接受了经皮冠状动脉介入治疗。共有4.2%的患者发生CIN；年龄较小、基础疾病(如中风和慢性肾脏疾病)、使用N-乙酰半胱氨酸和升高的ln(CTNFR)与CIN的发生有关。Ln(CTNFR1)增加(OR 6.32，95%CI 2.46~16.28，P
AimContrast-induced nephropathy (CIN) is an important cause of hospital-acquired acute kidney injury. An accurate understanding of the pathogenesis of CIN is crucial. The aim of this study was to evaluate the clinical role of circulating tumour necrosis factor receptors (cTNFRs) in CIN.MethodsFrom May 2013 to February 2014, 262 patients who underwent coronary angiography and/or percutaneous coronary intervention at Seoul National University Boramae Medical Center were enrolled. CIN was defined as either an increase in serum creatinine22.1mol/L or25% within 48 h after the procedure.ResultsDiabetes and chronic kidney disease accounted for 27.5% and 17.6% of the patients, respectively, and the mean age was 65 years. All patients received fluid therapy, and 36.3% underwent percutaneous coronary intervention. A total of 4.2% of the patients developed CIN; younger age, underlying diseases (e.g., stroke and chronic kidney disease), the use of N-acetylcysteine, and elevated concentrations of ln(cTNFRs) were associated with development of CIN. Increased values of ln(cTNFR1) (OR 6.32, 95% CI 2.46-16.28, P