The stability of the feedback negativity and its relationship with depression during childhood and adolescence
The stability of the feedback negativity and its relationship with depression during childhood and adolescence
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DOI：
10.1017/s0954579414001400
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发表时间：
2015-11-01
影响因子：
3.3
通讯作者：
Proudfit, Greg Hajcak
中科院分区：
文献类型：
--
作者：
Bress, Jennifer N.;Meyer, Alexandria;Proudfit, Greg Hajcak
消极反馈（FN）是由金钱奖励和损失引起的与事件相关的潜能；它被认为与奖励相关的神经活动有关，并与儿童和成人的抑郁症有关。在目前的研究中，我们对45名8至13岁的儿童进行了为期2年的研究，研究了FN的稳定性及其与青少年抑郁症的关系。从时间1到时间2，对金钱损失和金钱获得的反应FN表现出中等到强的可靠性(rs = .64和。分别为67);即使考虑到相关变量，这些关系仍然很重要。FN还显示了高会话内可靠性。此外，在时间1观察到的FN变钝与更大的抑郁之间的关系在时间2中重现，并且时间1的FN的大小预测了时间2的抑郁症状。这些发现与FN及其与抑郁症的关系在发展过程中保持一致的假设是一致的，并且FN可能前瞻性地预测后来的抑郁症状。目前的结果表明，FN可能适合作为青少年抑郁症状的生物标志物。
Feedback negativity (FN) is an event-related potential elicited by monetary reward and loss; it is thought to relate to reward-related neural activity and has been linked to depression in children and adults. In the current study, we examined the stability of FN, and its relationship with depression in adolescents, over 2 years in 45 8- to 13-year-old children. From Time 1 to Time 2, FN in response to monetary loss and in response to monetary gain showed moderate to strong reliability (rs = .64 and.67, respectively); these relationships remained significant even when accounting for related variables. FN also demonstrated high within-session reliability. Moreover, the relationship between a blunted FN and greater depression observed at Time 1 was reproduced at Time 2, and the magnitude of FN at Time 1 predicted depressive symptomatology at Time 2. These findings are consistent with the hypothesis that FN and its relationship with depression remain consistent over the course of development, and that FN may prospectively predict later depressive symptomatology. The current results suggest that FN may be suitable as a biomarker of depressive symptoms during adolescence.