Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates
Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates
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DOI：
10.1021/ol303130j
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发表时间：
2013-01-04
期刊：
影响因子：
5.2
通讯作者：
Cook, Silas P.
中科院分区：
文献类型：
--
作者：
Agrawal, Toolika;Cook, Silas P.
用伯烷基和仲烷基格氏试剂实现了芳基氨基磺酸酯和甲苯磺酸酯的铁催化交叉偶联。铁催化的交叉偶联反应的这项研究还探讨了异构化和β-氢化物消除的问题，与使用异丙基亲核试剂。虽然各种铁源在反应中是胜任的，但使用FeF 3中心点3 H（2）O对于使亲核异构化最小化至关重要。
The iron-catalyzed cross-coupling of aryl sulfamates and tosylates has been achieved with primary and secondary alkyl Grignards. This study of iron-catalyzed cross-coupling reactions also examines the isomerization and beta-hydride elimination problems that are associated with the use of isopropyl nucleophiles. While a variety of iron sources were competent in the reaction, the use of FeF3 center dot 3H(2)O was critical to minimize nucleophile isomerization.