Ghrelin concentration in cord and neonatal blood: Relation to fetal growth and energy balance
Ghrelin concentration in cord and neonatal blood: Relation to fetal growth and energy balance
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DOI：
10.1210/jc.2002-021350
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发表时间：
2003-11-01
影响因子：
5.8
通讯作者：
Kuroda, Y
中科院分区：
文献类型：
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作者：
Kitamura, S;Yokota, I;Kuroda, Y
为了探讨生长素释放肽与胎儿和新生儿生长参数及能量平衡的关系，我们检测了54例脐带血样本的血浆生长素释放肽浓度（男性，n = 34;女性，n = 20;胎龄，37.0 - 41.6周;出生体重，2206 - 4326 g）和47份新生儿血样（雄性，n = 27;雌性，n = 20;出生后第3 - 8天）。脐带血中的血浆ghrelin浓度范围为110.6 - 446.1 pmol/L（中位数为206.7 pmol/L），等于或高于正常体重成人。这些值与出生体重呈负相关（r =-0.40; P = 0.002），出生时长（r =-0.36，P = 0.007），胎盘重量（r =-0.35，P = 0.01），IGF-I浓度（r =-0.49; P = 0.0002），但与GH浓度无显著相关性（r = 0.22; P = 0.12）。小于胎龄儿的ghrelin浓度显著高于适于胎龄儿（P = 0.0008）。8例脐带血中静脉ghrelin浓度显著高于动脉ghrelin浓度（P = 0.01），提示胎盘是胎儿ghrelin的重要来源。在新生儿中，ghrelin浓度范围为133.0 - 481.7 pmol/L（中位数为268.3 pmol/L），显著高于脐带血（P< 0.0001）。这些结果表明，生长激素释放肽可能有助于胎儿和新生儿的生长。
To investigate the relationship between ghrelin and both fetal and neonatal growth parameters and energy balance, we measured plasma ghrelin concentrations in 54 cord blood samples (male, n = 34; female, n = 20; gestational age, 37.0 - 41.6 wk; birth weight, 2206 - 4326 g) and 47 neonatal blood samples ( male, n = 27; female, n = 20; postnatal d 3 - 8). The plasma ghrelin concentrations in cord blood ranged from 110.6 - 446.1 pmol/liter ( median, 206.7 pmol/liter), which were equal to or higher than those in normal weight adults. These values were inversely correlated with birth weight ( r = - 0.40; P = 0.002), birth length ( r = - 0.36; P = 0.007), placental weight ( r = - 0.35; P = 0.01), and IGF-I concentration ( r = - 0.49; P = 0.0002), but were not significantly correlated with the GH concentration r = 0.22; P = 0.12). The ghrelin concentrations in small for gestational age newborn were significantly higher than those in appropriate for gestational age newborns ( P = 0.0008). The ghrelin concentrations in the vein were significantly higher than those in the artery in 8 cord blood samples ( P = 0.01), which suggests that the placenta is an important source of fetal ghrelin. In neonates, the ghrelin concentrations ranged from 133.0 - 481.7 pmol/liter ( median, 268.3 pmol/liter), which were significantly higher than those in cord blood ( P< 0.0001). These results suggest that ghrelin may contribute to fetal and neonatal growth.