Aspirin Prevents the Disruption of the Blood–Aqueous Barrier in the Rabbit Eye
Aspirin Prevents the Disruption of the Blood–Aqueous Barrier in the Rabbit Eye
复制标题
阿司匹林防止兔眼血水屏障破坏
作者：
A. Neufeld;L. Jampol;M. Sears
急性创伤的哺乳动物的眼睛表现出刺激性反应，特征是结膜和虹膜充血，瞳孔缩小，血-房水屏障破裂，眼压一过性升高，随后相对低眼压。屏障被破坏的一个迹象是积极的房水耀斑，随着房水中血液蛋白浓度的增加。在兔眼中引起全部或部分这种反应的刺激包括结膜SAC1内注入氮芥末，皮下注射黑素细胞刺激素(MSH)2，抚摸虹膜3，4或角膜5，虹膜6的红外线照射，三叉神经的机械刺激7，以及前房穿孔8。
THE acutely traumatized mammalian eye shows an irritative response, characterized by hyperaemia of the conjunctiva and iris, miosis, disruption of the blood–aqueous barrier, and a transient increase in intraocular pressure followed by relative hypotony. One sign of the disruption of the barrier is a positive aqueous flare, with increased concentrations of blood proteins in the aqueous humour. Stimuli that elicit all or part of this response in the rabbit eye include nitrogen mustard instillation in the conjunctival sac1, subcutaneous injection of melanocyte stimulating hormone (MSH)2, stroking the iris3,4 or cornea5, infrared irradiation of the iris6, mechanical stimulation of the trigeminal nerve7, and anterior chamber paracentesis8.