Magnitude and role of wall shear stress on cerebral aneurysm - Computational fluid dynamic study of 20 middle cerebral artery aneurysms
Magnitude and role of wall shear stress on cerebral aneurysm - Computational fluid dynamic study of 20 middle cerebral artery aneurysms
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DOI：
10.1161/01.str.0000144648.89172.0f
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发表时间：
2004-11-01
期刊：
影响因子：
8.3
通讯作者：
Kirino, T
中科院分区：
文献类型：
--
作者：
Shojima, M;Oshima, M;Kirino, T
背景和目的：壁面切应力（WSS）是囊状脑动脉瘤形成的主要致病因素之一。应用计算流体动力学（CFD）方法分析大脑中动脉（MCA）动脉瘤内及瘤周WSS的大小和分布。CFD计算进行了使用我们原来的有限元求解器与牛顿流体性质的假设血液和刚性壁属性的血管和aneurysm.Results-the最大WSS在计算区域往往发生在动脉瘤的颈部附近，而不是在其尖端或水泡。最大WSS的幅度为14.39+/-6.21 N/m（2），是血管区域平均WSS（3.64+/-1.25 N/m（2））的4倍。动脉瘤区的平均WSS（1.64 ± 1.16 N/m2）显著低于血管区（P
Background and Purpose-Wall shear stress (WSS) is one of the main pathogenic factors in the development of saccular cerebral aneurysms. The magnitude and distribution of the WSS in and around human middle cerebral artery (MCA) aneurysms were analyzed using the method of computed fluid dynamics (CFD).Methods-Twenty mathematical models of MCA vessels with aneurysms were created by 3-dimensional computed tomographic angiography. CFD calculations were performed by using our original finite-element solver with the assumption of Newtonian fluid property for blood and the rigid wall property for the vessel and the aneurysm.Results-The maximum WSS in the calculated region tended to occur near the neck of the aneurysm, not in its tip or bleb. The magnitude of the maximum WSS was 14.39+/-6.21 N/m(2), which was 4-times higher than the average WSS in the vessel region (3.64+/-1.25 N/m(2)). The average WSS of the aneurysm region (1.64+/-1.16 N/m(2)) was significantly lower than that of the vessel region (P