Angiocrine functions of organ-specific endothelial cells.
Angiocrine functions of organ-specific endothelial cells.
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DOI：
10.1038/nature17040
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发表时间：
2016-01-21
期刊：
影响因子：
64.8
通讯作者：
Ding BS
中科院分区：
文献类型：
--
作者：
Rafii S;Butler JM;Ding BS
血管毛细血管的内皮细胞不仅仅是输送血液的被动管道。组织特异性内皮细胞建立专门的血管龛，部署特定的生长因子，称为血管分泌因子，积极参与诱导，指定，图案化和引导器官再生和维持稳态和代谢。血管分泌因子在损伤后上调，协调组织特异性再生干细胞和祖细胞的自我更新和分化，使其成为功能性器官。揭示生理水平的血管分泌因子在空间和时间上产生的精确机制，并通过器官型内皮细胞分布到重建细胞，将为驱动器官修复而不留下疤痕奠定基础。
Endothelial cells lining blood vessel capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establish specialized vascular niches that deploy specific sets of growth factors, known as angiocrine factors, which actively participate in inducing, specifying, patterning, and guiding organ regeneration and maintaining homeostasis and metabolism. Angiocrine factors upregulated in response to injury orchestrates self-renewal and differentiation of tissue-specific repopulating resident stem and progenitor cells into functional organs. Uncovering the precise mechanisms whereby physiological-levels of angiocrine factors are spatially and temporally produced, and distributed by organotypic endothelium to repopulating cells, will lay the foundation for driving organ repair without scarring.