Zwitterionic Photografted Coatings of Cochlear Implant Biomaterials Reduce Friction and Insertion Forces.
Zwitterionic Photografted Coatings of Cochlear Implant Biomaterials Reduce Friction and Insertion Forces.
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DOI：
10.1097/mao.0000000000003288
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发表时间：
2021-12-01
期刊：
影响因子：
--
通讯作者：
Hansen MR
中科院分区：
文献类型：
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作者：
Bennion DM;Horne R;Peel A;Reineke P;Henslee A;Kaufmann C;Guymon CA;Hansen MR
将光接枝的两性离子涂层应用于耳蜗植入物（CI）生物材料将减少摩擦力和插入力。在电极阵列植入期间，最小化耳蜗内创伤的策略对于优化结果（包括保留残余听力）至关重要。为此，在相关生物材料上的薄膜两性离子水凝胶涂层的进展可能显示出希望，除了这些材料用于减少颅内异物反应的潜力之外。使用最近设计的一个步骤的过程中，来自两性离子磺基甜菜碱甲基丙烯酸酯（SBMA）的薄膜涂层进行光聚合和光接枝到聚二甲基硅氧烷（PDMS，硅橡胶）样品的表面，也CI阵列从两个制造商。荧光素染色和扫描电子显微镜与能量色散X射线光谱验证和表征的涂层。摩擦测量法用于测量未涂覆和涂覆的PDMS与合成和生物组织之间的摩擦系数。在将无涂层（n=9）和有涂层（n=9）CI电极阵列插入人尸体耳蜗期间获得力传感器测量值。PDMS的SBMA薄膜涂层导致与钢、陶瓷和豚鼠皮肤组织的摩擦系数降低>90%（p<0.0001）。我们采用了一种新的方法，在植入物电极阵列部分的地理选择性区域应用共价键合、耐用和均匀的涂层。图像分析证实了具有SBMA聚合物膜的PDMS系统和CI电极阵列的均匀涂覆。在将电极阵列插入人尸体耳蜗期间，SBMA涂层使插入期间的最大力降低约40%（p<0.001），并降低了力的变化性和插入的总功。在PDMS和电极阵列上的薄膜SBMA光接枝涂层显著降低了尸体耳蜗中的摩擦系数和插入力。这些令人鼓舞的发现支持CI电极阵列的薄膜两性离子涂层可以潜在地减少插入创伤，从而促进改善听力和其他长期结果。
Application of photografted zwitterionic coatings to cochlear implant (CI) biomaterials will reduce friction and insertion forces Strategies to minimize intracochlear trauma during implantation of an electrode array are critical to optimize outcomes including preservation of residual hearing. To this end, advances in thin-film zwitterionic hydrogel coatings on relevant biomaterials may show promise, in addition to the potential of these materials for decreasing the intracochlear foreign body response. Using a recently designed one-step process, thin-film coatings derived from zwitterionic sulfobetaine methacrylate (SBMA) were photopolymerized and photografted to the surface of polydimethylsiloxane (PDMS, silastic) samples and also to CI arrays from two manufacturers. Fluorescein staining and scanning electron microscopy with energy-dispersive X-ray spectroscopy verified and characterized the coatings. Tribometry was used to measure the coefficient of friction between uncoated and coated PDMS and synthetic and biological tissues. Force transducer measurements were obtained during insertion of uncoated (n=9) and coated (n=9) CI electrode arrays into human cadaveric cochleae. SBMA thin-film coating of PDMS resulted in >90% reduction in frictional coefficients with steel, ceramic, and dermal tissue from guinea pigs (p<0.0001). We employed a novel method for applying covalently bonded, durable, and uniform coating in geographically selective areas at the electrode array portion of the implant. Image analysis confirmed uniform coating of PDMS systems and the CI electrode arrays with SBMA polymer films. During insertion of electrode arrays into human cadaveric cochleae, SBMA coatings reduced maximum force by ~40% during insertion (p<0.001), as well as decreasing force variability and the overall work of insertion. Thin-film SBMA photografted coatings on PDMS and electrode arrays significantly reduce frictional coefficients and insertional forces in cadaveric cochleae. These encouraging findings support that thin-film zwitterionic coating of CI electrode arrays may potentially reduce insertional trauma and thereby promote improved hearing and other long-term outcomes.