Nrf2 in health and disease: current and future clinical implications
Nrf2 in health and disease: current and future clinical implications
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DOI：
10.1042/cs20150436
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发表时间：
2015-12-01
期刊：
影响因子：
6
通讯作者：
Wruck, Christoph Jan
中科院分区：
文献类型：
--
作者：
Al-Sawaf, Othman;Clarner, Tim;Wruck, Christoph Jan
转录因子Nrf2（核因子红细胞2相关因子2）是人体氧化应激防御的主要调节因子。由于Nrf2调节大量细胞保护基因的表达，因此它在预防多器官退行性疾病中起着至关重要的作用。因此，它已成为研究的焦点，作为一个药理学目标，可用于预防和治疗慢性疾病，如多发性硬化症，慢性肾脏疾病或心血管疾病。本综述总结了基础研究中有希望的发现，并显示了哪些Nrf2靶向治疗目前正在临床试验中进行研究，哪些药物已经进入临床实践。
The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is a major regulator of oxidative stress defence in the human body. As Nrf2 regulates the expression of a large battery of cytoprotective genes, it plays a crucial role in the prevention of degenerative disease in multiple organs. Thus it has been the focus of research as a pharmacological target that could be used for prevention and treatment of chronic diseases such as multiple sclerosis, chronic kidney disease or cardiovascular diseases. The present review summarizes promising findings from basic research and shows which Nrf2-targeting therapies are currently being investigated in clinical trials and which agents have already entered clinical practice.