An mPOA-ARC AgRP pathway modulates cold-evoked eating behavior
An mPOA-ARC AgRP pathway modulates cold-evoked eating behavior
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mPOA-ARC AgRP 通路调节寒冷诱发的饮食行为
DOI：
10.1016/j.celrep.2021.109502
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发表时间：
2021
期刊：
影响因子：
8.8
通讯作者：
Ju Huang
中科院分区：
文献类型：
--
作者：
Shuo Yang;Yu Lin Tan;Xiaohua Wu;Jingjie Wang;Jingjing Sun;Anqi Liu;Linhua Gan;Bo Shen;Xiaocui Zhang;Yu Fu;Ju Huang
食欲增强是低温下行为体温调节的一种方式。神经回路介导行为体温调节和能量稳态之间的串扰仍有待阐明。我们发现下丘脑弓状核（ARC）中的促氧性刺痛症相关神经肽（AgRP）神经元在低温暴露下被深度激活。在冷刺激下，ARCAgRP神经元的钙信号表现为即时反应模式。内侧视前区（mPOA）的冷反应神经元与ARCAgRP神经元形成兴奋性突触。抑制ARCAgRP神经元或arc投射的mPOA神经元均可减弱冷诱发进食，而激活mPOA到arc投射的mPOA神经元可增加食物摄入。这些发现揭示了mPOA-ARCAgRP神经通路调节冷诱发摄食行为。
Enhanced appetite occurs as a means of behavioral thermoregulation at low temperature. Neural circuitry mediating this crosstalk between behavioral thermoregulation and energy homeostasis remains to be elucidated. We find that the hypothalamic orexigenic agouti-related neuropeptide (AgRP) neurons in the arcuate nucleus (ARC) are profoundly activated by cold exposure. The calcium signals in ARCAgRP neurons display an immediate-response pattern in response to cold stimulation. Cold-responsive neurons in the medial preoptic area (mPOA) make excitatory synapses onto ARCAgRP neurons. Inhibition of either ARCAgRP neurons or ARC-projecting mPOA neurons attenuates cold-evoked feeding, while activation of the mPOA-to-ARC projection increases food intake. These findings reveal an mPOA-ARCAgRP neural pathway that modulates cold-evoked feeding behavior.